The latest issue of Cancer Gene Therapy, a subjournal of the British Nature series, published the results of a collaborative study between Associate Professor Tao Li, Department of General Surgery, Qilu Hospital, Shandong University, and Department of Liver Surgery, Zhongshan Hospital, Fudan University. The study found that small doses of aspirin significantly increased the apoptosis-promoting and growth-inhibiting effects of interferon-α in hepatocellular liver cancer, which was achieved by activating the JAK1/STAT1 pathway. This study has positive implications for reducing the resistance of hepatocellular carcinoma to interferon-α and improving the therapeutic effect of interferon-α on hepatocellular carcinoma, providing a new therapeutic strategy for clinical improvement of hepatocellular carcinoma.