The traditional idea of “no filial piety, no offspring” is strongly feudal and should be discarded, but a man in his prime who cannot have his own newborn child because of infertility is also a distressing thing. According to statistics, about 15% of married couples are infertile, with male infertility accounting for at least 50%. At present, in exploring the etiology of infertility, the influence of the reproductive organs and fluid function of both men and women is often considered, and less research has been done on the influence of drugs. In addition to the normal use of steroidal contraceptives or the use of contraceptives can cause infertility, with the development of the medical and chemical industries, many chemical drugs can affect the function of the reproductive organs or changes in the secretion fluid, thus causing male infertility. There are many factors that can affect male fertility, but usually it is easy to draw attention to diseases of the reproductive and endocrine systems, while other factors are often overlooked. Here are some of the drugs that may affect men’s fertility according to clinicians’ observations. 1, may affect the erection of drugs such as ethylene estradiol, thiisonicotinamide, trichloroethylene, tachyzoe, guide sleep energy, Telden, triphenylethanol, phenelzine, chlorpromazine, beta-blockers, hydrazinebendazide, cyproheptadine, anti-inflammatory pain, gastritis, amphetamine, dimethyl ergonovine, atropine, dicyclomine hydrochloride, etc. 2.Drugs that may affect reproductive function or cause impotence include methotrexate, antomin, lipid-lowering propylene glycol, adrenocorticotropic hormone, digoxin, dihydrocortisone, barbiturate, ambrisentin, phenothiazines, and phentolamine. 3, may reduce the number of spermatozoa are nitrogen mustard phenylbutyrate, colchicine, cotrimoxazole, salazosulfapyridine, hydrogenated prednisone, sodium cod liver oil acid, antipyretic analgesic aspirin, paracetamol, botrytisone, etc. 4.The drugs metformin, ranitidine, amphotericin, methadone, morphine, and anti-hypertensive drugs such as hexahydroquinone, ampicillin, mecamylamine, guanethidine, chlorpheniramine, benzylguanidine, fluorocarbobenzene, reserpine, antihypertensive, methyldopa, cardiac arrest and ketoconazole, etc., which reduce libido or lead to impotence and decrease in sperm count. 5.Drugs that cause lack of semen, no sperm or testicular atrophy include cyclophosphamide and leucovorin. 6.Drugs that may cause testicular atrophy or degeneration include leucovorin, nitrogen mustard hydrochloride, hydroxyurea, botrytisone, etc. 7.Drugs that may cause hypogonadism, reduced testosterone production and impotence by affecting the secretion of pituitary gonadotropins include Librium, promethazine, propafenone, methiodiazine, sulpiride, etc. 8, may lead to ejaculation disorder drugs are monoamine chloride enzyme inhibitors, tricyclic antidepressants, Antan, guanethidine, Librium, colistin, phenibut, potassium carbonate, reserpine, etc. 9. The drugs that may affect sperm motility are insulin, etc. It is generally believed that all of the above drugs may be indirectly caused by the normal physiological function of the reproductive organs and male infertility, and also with the dose, time and total amount taken. Therefore, men who suffer from infertility and are looking forward to having a smart, healthy child must take the above drugs under the guidance of a doctor to avoid the occurrence of pharmacogenic male infertility.