1, the pathological features of the condyloma acuminata: mainly incomplete keratinization, spiny layer highly hypertrophic, papillomatous hyperplasia, epidermal protrusion thickening, prolonged, the degree of hyperplasia can resemble pseudo-epithelioma-like. The spiny cells and basal cells had a considerable number of nuclear divisions and resembled carcinoma. However, the cells were regularly arranged and the boundary between the proliferating epithelium and dermis was clear. It is characterized by the formation of vacuoles in the granular layer and the upper cells of the spiny layer. These vacuolated cells are larger than normal, with light cytoplasmic coloration and large, round, deeply basophilic nuclei in the center. The dermis is usually edematous, with dilated capillaries and a dense, chronic inflammatory infiltrate. In giant warts, the epidermis grows extremely downward, replacing the underlying tissue and easily mixing with squamous cells, so multiple biopsies are required. If there is a tendency to develop slowly, it is a low malignant process, the so-called wart-like cancer, must cause patients and clinicians a high degree of concern. 2, genetic diagnosis of condyloma acuminata To date, HPV is difficult to detect with traditional viral culture and serological techniques, the main experimental diagnostic techniques are nucleic acid hybridization. The PCR test developed in recent years has the advantages of specificity, sensitivity, simplicity and speed, opening up new avenues for HPV detection