There is no such thing as a blood mole of liver cancer in medical terminology. What is commonly referred to as blood mole of liver cancer is actually a skin manifestation known as spider mole. It is generally red in color and relatively small in localized area. It also occurs in other liver diseases. Spider nevus gets its name because of its spider-like appearance. The spider nevus is located on the surface of the skin and it has a central red vascular spot, called the central small artery, surrounded by radiating small arterial vascular branches. By compressing this red central vascular point with the tip of a finger or cotton swab, the surrounding radial small arterial branches will quickly fade. After releasing the pressure on the central point, the blood in the surrounding radial vessels rapidly refills and reappears as before. The small central artery protruding from the skin resembles the body of a spider, and the radial distribution of tiny blood vessels resembles multiple spider legs, hence the clinical image of a spider nevus. They tend to be multiple lesions. These lesions are most commonly found in areas of the body with superior vena cava drainage, such as the face, neck, above the upper trunk nipple line, and arms. The development of these skin nevi in patients with liver cancer is associated with abnormal liver function or failure. Due to the presence of estrogen in the body, this hormone can cause dilatation of the body’s tiny blood vessels. Abnormal liver function or failure after cirrhosis, acute and chronic hepatitis can greatly diminish the inactivation of estrogen, resulting in spider nevi. It is important to note that spider nevus is not a clinical manifestation unique to liver cancer. Hepatitis, cirrhosis and even normal pregnant women and children can also develop this kind of spider nevus. The diagnosis of liver cancer must be determined by other related tests.