Staging of chronic granulomatous leukemia

Chronic granulocytic leukemia is divided into three phases: 1. Chronic phase: The chronic phase will show weakness, night sweats, emaciation, and abdominal distension. Do routine blood tests, will find high white blood cells, high platelets, a slight bit of anemia, or normal hemoglobin, physical examination found that the spleen is enlarged, if you do a bone puncture, will find that the bone marrow inside the primitive granulocyte count, that is, the granulocytes of infants and children so old in less than 10%, most of them are adolescents, middle and late young granulocytes are higher. If the chromosome is checked, the typical translocation of chromosomes 9 and 22 is found, and the fusion gene is checked, and a positive bcr/abl fusion gene will be found. The chronic phase is differentiated by laboratory tests in addition to symptoms, and not simply by what one feels. If the chronic phase does not undergo regular treatment, it may enter the accelerated phase in 3-4 years; 2. Accelerated phase: the accelerated phase will show weakness and wasting significantly aggravated, in this case, instead, there is an increase in spleen aggregation, a significant increase or significant decrease in platelets, or another significant increase or significant decrease in white blood cells, and bone aspiration will reveal that the primitive granulocyte count exceeds 10%-19% and the basophils in the blood The bone aspiration will reveal a primitive granulocyte count of more than 10%-19% and a basophil count of more than 20%. In addition, the chromosome will show that in addition to the translocation of chromosomes 9 and 22, other chromosomes appear, such as chromosome 8, chromosome 19 or other chromosomal abnormalities, which is called the accelerated phase; 3. In addition, the primitive cells will increase to 20% and reach the standard of acute leukemia, most of the white blood cells will increase sharply and platelets drop significantly, if the acute phase does not go through timely treatment, it may be life-threatening for six months to one year.