In contact with patients, many patients take a positive HPV antibody result and ask if they are infected with condyloma acuminatum. Today, in response to this question, what is the significance of a positive specific HPV antibody? Human papillomavirus) is an epitheliophilic virus that is widely distributed in humans and animals and has a high degree of specificity. It is a small DNA virus, 45-55 nm in diameter, with an icosahedral, three-dimensional symmetric capsid containing 72 capsid particles and no capsule membrane. Clinically, there are as many as several dozen subtypes of HPV, and different subtypes can cause different diseases. HPV can be divided into two categories, low-risk and high-risk, depending on the degree of pathogenicity or cancer risk of HPV subtypes. Low-risk HPV mainly causes ectopic warts on the anal skin and male external genitalia, female labia majora and minora, urethra, lower vagina and low-grade cervical intraepithelial neoplasia, with viral subtypes HPV6, 11, 30, 39, 42, 43 and HPV44. High-risk HPV can cause external genital warts, but more importantly, external genital cancer, cervical cancer and high-grade cervical intraepithelial neoplasia. The main viral subtypes are HPV types l6, 18, 31, 33, 35, 45, 51, 52, 56, 58 and HPV 61. Common clinical conditions include: common warts (mainly types 1, 2, and 4) called prickly wart or wart, which can occur on any part of the body, with the hands being the most common. Plantar warts (mainly types 2 and 4) grow beneath the callus and can be painful to walk on. Flat warts (mainly type 3, 10) occur on the face, hands, arms, knees, and are multiple. Bowen-like papulosis (mainly types 39 and 42), etc. HPV infects humans mainly through direct or indirect contact with contaminated objects or sexual transmission. After the virus invades the body, it stays in the skin and mucous membranes at the site of infection and does not produce viremia. Within 1 to 2 months after the appearance of the infected lesion, the corresponding antibody is produced in the blood against the infected virus, and at this time, if a blood test is drawn, the result will be positive and the positive rate is about 50-90%. However, this positive result is only positive for antibodies, not for the virus. In other words, what is detected in the blood is the corresponding antibodies against HPV, not the virus itself, because the virus lives only in the superficial mucous membrane of the skin at the site of infection and is not normally found in the blood. Regardless of the type of HPV infection, antibodies will be present in the serum after a period of time. The antibodies persist for months to years after the lesions have subsided, but are not protective. In other words, an ordinary person with a wart who goes to have a blood test for HPV is likely to have a positive result. However, at this point we cannot rely on this positive result to indicate that the person has an STD or condyloma acuminatum. So, when a patient gets a positive result from a blood test, it only means that what can be detected in the blood is HPV antibodies, not the virus. It means that at some time in the past, the patient has been infected with the hpv virus, but not necessarily the type of strain that causes STDs acromegaly and does not mean that it is necessarily acromegaly and STDs. The use of blood tests to confirm the diagnosis of warts or STDs is also used in clinical tests only as a reference basis and does not have a diagnostic conclusion.