Amniocentesis and DNA testing have their own advantages, disadvantages and indications, and it is impossible to compare which one is better, and needs to be chosen according to the specific situation. 1. Amniocentesis: It is a prenatal diagnostic method that can diagnose chromosomal diseases by extracting fetal cells from amniotic fluid under ultrasound mediation. It is invasive and carries the risk of fetal miscarriage, fetal injury, chorioamnionitis, and hemorrhage. Pregnant women with symptoms of miscarriage, infection, or abnormal coagulation are prohibited from undergoing the test. 2. DNA test: The DNA fragments in plasma are examined and analyzed by taking peripheral blood of pregnant women to determine the risk of the fetus suffering from trisomy 18, trisomy 13, and trisomy 21. Because it is a non-invasive test, it does not increase the risk of fetal miscarriage and is over 95% accurate with some false positives. If there is any abnormality, further amniocentesis is needed to confirm the diagnosis. It is recommended that high-risk pregnant women go to regular hospitals, consult with specialized doctors in detail, and make choices according to specific circumstances.