Case presentation: Female patient, 25 years old. She was admitted to the hospital because “right adrenal tumor had been found on physical examination for 1 month”. Physical examination: a hard mass could be found in the right upper abdomen, which could not be pushed, no pressure pain, and no other special features. MRI suggested a large tumor in the right adrenal gland. PET/CT showed that the right adrenal tumor was benign. The patient was admitted to the hospital and underwent surgery in our department after the relevant examinations. The operation went very well, with 100ml intraoperative bleeding. Postoperative pathology: right adrenal ganglion cell neuroma. What is a ganglioneuroma? Ganglion cell neuroma is a rare benign tumor originating from primitive neural crest cells, consisting of mature ganglion cells, Schwann cells and nerve fibers, usually originating from the sympathetic chain of the paraspinal column. They are usually found in the retroperitoneum, posterior mediastinum, and neck, and are rare in the adrenal gland. Most of the tumor cells have no endocrine function, so they do not cause clinical symptoms and signs caused by corresponding endocrine dysfunction, but some non-specific symptoms related to tumor enlargement or hemorrhage or necrosis may appear, such as back pain, lack of appetite, emaciation, fever and so on. Currently, most adrenal ganglioneuroma are considered benign tumors with good prognosis after complete surgical resection.