Now to eat outside, less drinking, but for beer and seafood, many times many people although already salivating, but had to say
NO, and then helplessly say I have high uric acid, I have ventilation, forget about it, etc. But what is uric acid, what causes high uric acid? But what is uric acid, what causes high uric acid? What should I do if I have high uric acid? How much do you know about uric acid? Let’s learn together.
I. What is uric acid?
Uric acid is the main metabolic product of birds and reptiles, slightly soluble in water, easy to form crystals. The product of normal human urine is mainly urea, containing a small amount of uric acid.
Second, how is uric acid formed?
Nucleic acid is a macromolecular compound, nucleic acid is composed of numerous nucleotides. Each nucleotide is composed of three parts, a phosphate molecule, a pentose (five-carbon sugar) and a base (purine or pyrimidine). The genetic material DNA (deoxyribonucleic acid) in the nucleus of living cells and RNA (ribonucleic acid) in the cytoplasm consists of hundreds of thousands, millions or even tens of millions of nucleotides. In turn when nucleic acids are oxidized and broken down one of the products is purines, so purines are said to be the building blocks of cells. Older cells in the body, as well as food, especially purine-rich food (such as animal offal, seafood, etc.) have purines as a product of the oxidative breakdown of nucleic acids during metabolism in the body (this endogenous purine accounts for 80% of total purines). After purine is produced in the body, it is oxidized again in the liver to (2,6,8C trioxopurine), also known as uric acid. 2/3 of uric acid is excreted in the urine through the kidneys, and 1/3 through feces and sweat. It can be seen that purine is the metabolic product of oxidative decomposition of nucleic acid, while uric acid is the metabolic end product of purine, in which the purine ring is not unraveled.
Third, what are the dangers of uric acid to people?
Under normal circumstances, there are about 1200 mg of uric acid in the body, and about 600 mg of new production and 600 mg of excretion per day are in a balanced state. However, if the body produces too much uric acid to excrete or the uric acid excretion mechanism is degraded, the body will retain too much uric acid, and when the blood uric acid concentration is greater than 7 mg/dL, the body fluid will become acidic and affect the normal function of human cells, and long-term neglect will lead to gout. In addition, excessive fatigue or insufficient rest can also lead to a relative slowdown in metabolism, leading to the development of gout.
All the uric acid in the blood is filtered from the glomerulus, 98% of which is secreted into the glomerular lumen in the middle part of the proximal tubule, then 50% of the reabsorbed uric acid is secreted into the glomerular lumen in the middle part of the proximal tubule, and 40%-44% is reabsorbed in the straight part of the proximal tubule, and only 6%-10% of uric acid is excreted. The rate of uric acid production and excretion in normal human body is relatively constant. The changes in uric acid content in body fluids can fully reflect the status of metabolic and immune functions in the human body.
Fourth, what are the clinical manifestations of uric acid hazards?
In different stages, there are different performances.
1. Asymptomatic hyperuricemia: Blood tests can reveal an increase in blood uric acid concentration, but no arthritis, hyperuric acid. The clinical symptoms such as stone or kidney stone. Unless laboratory tests are done during this period, it is usually not easy to detect. Asymptomatic hyperuric acid. The hyperuricemia may persist for 10 to 20 years, and some may remain free of hyperuric acid for life. Generally speaking, the higher the blood uric acid level, the greater the risk of hyperuricemia.
2. Acute hyperuricemic arthritis: It can develop in all seasons, most often in spring and autumn. Acute attacks can be triggered by local injury to the joints, heavy meals, excessive fatigue, cold and wet, certain drugs, infections and surgical procedures. These factors can cause the already supersaturated uric acid to form needle-like crystals and deposit them in the synovial fluid, and the crystals will be swallowed by the leukocytes in the body as foreigners and release inflammatory factors after being swallowed, causing an acute attack.
3. Uric acid nephropathy (gout nephropathy) is a condition in which the concentration of uric acid in the blood increases to a supersaturated state and uric acid crystals are deposited in the kidneys, causing lesions. The prevalence of uric acid nephropathy in Europe and the United States is about 0.3%, and the European Dialysis Transplantation Association reported that end-stage renal failure caused by gout accounts for 0.6 to 1.0%. The increased intake of protein and purine-rich foods in our diet has increased the incidence of gout. Gout is mostly seen in obese, meat and alcoholics, men are significantly higher than women, the average age of attack is 45 years, and the occurrence of gout nephropathy more than 10 years after the onset of hyperuricemia.
V. What should I do if my uric acid is high?
According to the mechanism of uric acid production, we in turn deduce: to prevent and treat gout well we should reduce the production of uric acid, to reduce the production of uric acid we should reduce the purine in the body, to reduce the purine in the body we should reduce the oxidation and decomposition of nucleic acid, and the intake of purine, and at the same time strengthen the elimination of uric acid. Therefore the measures are.
1, to prevent the oxidation and decomposition of nucleic acids in the cells: this is the main event, the main method is to take some long-term anti-nucleic acid oxidation substances, such as astaxanthin, anthocyanins and so on. Doing this well can reduce the production of endogenous purines by 80%.
2, high uric acid (gout) diet control: diet is the main source of exogenous purines and uric acid in patients with high uric acid (gout), uric acid is mainly from the breakdown of nucleotides in the diet. It accounts for about 20% of the total uric acid in the body. For hyperuricemia, endogenous metabolic disorders are more important than exogenous factors. If blood uric acid is high and purines are high, a chain of reactions is formed for gout. Therefore what you can’t eat and what you can eat when you have high uric acid (gout) is quite important, and the patient must be. While treating high uric acid (gout), it is important to pay attention to. The problem of high uric acid (gout) diet.
3, to promote the excretion of uric acid: moderate alkalinization of urine (baking soda and the like), a small amount of alkaline items will be directly neutralized in the digestive tract, so to play a role in neutralizing uric acid, then the intake of alkaline items must reach a certain amount, after the full reaction with acidic digestive juices such as stomach acid to enter the bloodstream to contact uric acid. The acid-base balance of the body is broken long before that.
Six, how to prevent high uric acid disease?
1, more exercise, must not do strenuous exercise, so as not to overwork the joints. It is best to choose aerobic exercises such as swimming, tai chi, table tennis and so on to reduce weight.
2, drink more water. It is best to drink soda, alkaline water or Yiyuan Herbal Acid Reducing Tea and the like, at least plain water, the daily urine output should be controlled at about 2000ml is the best, soda or baking soda to take too much easy to cause excessive sodium intake. Do not drink strong tea, drinks.
3, eat less meat. Why do not I say “do not eat meat” it? Of course meat is to eat a little, animal fat and animal protein with other food is not replaceable, but also the body is necessary, but must control the amount. Experts point out that seafood, animal offal, all kinds of meat soup and hot pot is to be strictly forbidden. Otherwise, the inordinate diet meat, you will be foregone.
4, the prohibition of alcohol. Especially beer, if you really have an alcohol addiction, you can drink some red wine in moderation, other alcohol is not drunk or strictly limited.
5, develop the habit of daily or often with hot water foot bath, preferably with a foot bath that can be automatically heated, not less than 20 minutes each time, not more than 30 minutes, can wash the whole body slightly sweaty best. In the foot bath, you can properly add some blood circulation and blood stasis of Chinese medicine. However, gout acute attack period is strictly prohibited foot bath.
6, eat more vegetarian, but not all vegetarian food should eat more, eat more purple eggplant, Shanghai green, lettuce. Green vegetables avoid spinach, and then all the legumes should be eaten less or not. Eat more fruits, all kinds of fruits are composed of carbohydrates, so that the body plays a positive role in alkaline, especially more cherries.
7, work and rest, pay attention to sleep, relaxed mind, optimistic face. Check uric acid once every six months, and strive to control it at about 350.
Reduce uric acid through reasonable diet:
1, should supply sufficient carbohydrates and fat, patients can eat carbohydrate-rich rice, steamed buns, pasta, etc..
2, cooking methods more braised, boiled, boiled, steamed, blanching, etc., less frying, frying methods. Food should be as easy to digest.
3, more use of food rich in vitamin B1 and vitamin C. Available foods: rice, noodles, milk, eggs, fruits and various vegetable oils. And vegetables in addition to lobster, celery, cauliflower, spinach, the other can be eaten.
4, prohibit animal offal, roe, bone marrow, sardines, oysters, shrimp, mackerel, mussels, minced meat, liver, kidney, brain, clams, crab, fish, broth, chicken soup, peas, lentils, mushrooms, etc., a variety of strong condiments and strengthen the nervous excitement of food such as wine (especially beer), tea, coffee, spicy products, etc.
5, maintain the ideal weight, overweight or obese should reduce weight. However, weight loss should be gradual, otherwise it is easy to cause acute attacks of ketosis or gout.
6, cherry powder contains highly active cherry flavonoid and cherry pigment, inhibit uric acid synthesis, help uric acid excretion, pain and anti-inflammatory.
7, thyme leaf powder contains a high value of thymol, can relieve pain and anti-inflammatory, diuretic, can excrete excessive uric acid in the body.
8, celery seed powder is rich in isoflavones, can and neutralize the acidic body, promote joint and tissue health, and inhibit uric acid synthesis.
9, Yiyuan Herbal Tea is made of Chinese herbs, which can enhance kidney function and accelerate uric acid excretion, thus reducing uric acid.
10.Mint leaf extract, very strong diuretic effect, which is an inhibitor of xanthin oxidase, restores autonomous beat uric acid and reduces uric acid level.
11, vitamin C, anti-inflammatory and pain relief, repair the kidneys, reduce the level of urea in the body, and promote the absorption of the other four components
Seven, what is the clinical significance of increased blood uric acid?
1) Increased blood uric acid is mainly seen in gout, but a few gout patients have normal blood uric acid measurement during gout attack. The increased blood uric acid without gout attack is called hyperuricemia.
2) When the cell proliferation cycle is fast and nucleic acid catabolism increases, such as leukemia and other malignant tumors, multiple myeloma, and true erythrocytosis, serum uric acid values are commonly increased. The increase of blood uric acid is more obvious after chemotherapy for tumors.
3) In renal hypofunction, it is often accompanied by increased serum uric acid. This can be seen in renal diseases such as acute and chronic nephritis, and other advanced stages of renal diseases such as renal tuberculosis, pyelonephritis, and hydronephrosis.
4) In chloroform poisoning, carbon tetrachloride poisoning and lead poisoning, canker sores, pregnancy reactions and consumption of foods rich in nucleic acid can cause an increase in uric acid in the blood.
VIII. Frequently asked questions about uric acid
What can’t I eat if I have high uric acid (gout)?
1, animal offal: such as pancreas, liver, kidney, bone marrow, large intestine (high purine content). Vegetables: spinach, baby carrots, etc;
Special note: Because spinach and other plants rich in oxalic acid, easily lead to high oxalic acid urine multiplied, making a sharp increase in uric acid, increasing the burden on the kidneys.
2, seafood, shellfish, etc.: special note: lobster, crab, oysters, herring, anchovies, salmon, tuna, white fish and other seafood, shellfish, green algae can not eat the reason: because these foods are rich in polysaccharides, high protein, etc., these will increase the burden of kidney decomposition, uric acid increased, so it is not advisable to eat more. But some of these foods are rich in nature’s strongest antioxidant astaxanthin, which can reduce the source of uric acid by 80%, how to “remove the dross and take the essence”? The best way is to use astaxanthin to supplement the gout patients, and should not use “eat puffer fish” to eat the above food to supplement the astaxanthin.
3, treatment: there are mainly western medicine treatment and Chinese medicine treatment two methods. Western medicine includes benzbromarone, propoxur and allopurinol, which promote uric acid excretion and inhibit the production of uric acid, which can be harmful for a long time.