Bile is secreted by hepatocytes, and in the non-digestive period, bile is transferred to the gallbladder via the hepatic ducts for storage; in the digestive period, bile can be directly discharged in large quantities to the duodenum from the liver and gallbladder to promote the digestion and decomposition of fats and the absorption of fat-soluble vitamins. Insufficient bile secretion is related to daily life habits or liver and gallbladder diseases: i. Physiological factors are usually related to recent dietary conditions, such as irregular diet, skipping breakfast, or single food, insufficient nutrition, and so on. These bad habits can lead to insufficient raw materials for liver cells to synthesize bile, and thus bile insufficiency occurs. It can be recovered by improving life habits. Second, pathological factors 1, liver disease: liver function abnormalities such as chronic hepatitis, liver occupying lesions such as malignant tumors, can lead to bile synthesis, metabolism, there are serious abnormalities, will also cause bile secretion insufficiency; 2, gallbladder disease: such as cholecystitis, biliary obstruction, etc., resulting in gallbladder failure, so that bile can not be discharged to the duodenum; 3, endocrine disease: bile secretion by the nervous and humoral factors of the Double regulation. Acetylcholine released after vagus nerve impulse can act on hepatocytes and gallbladder to promote bile secretion and gallbladder contraction. And gastrin produced by G cells can also act directly on hepatocytes to promote bile secretion. In addition, glucagon, bile salts in bile, and cholecystokinin also play an important role in the secretion and excretion of bile. Abnormalities in these factors can lead to inadequate bile secretion.