1. Different types of gallbladder stones with obvious clinical symptoms, such as simple chronic cholecystitis with stones, chronic atrophic cholecystitis with stones, filled gallbladder stones, chronic cholecystitis with embedded stones. 2. Polypoid lesions of gallbladder. 3, asymptomatic simple gallbladder stones, the following patients should take LC treatment: (1) ceramic gallbladder, because of its gallbladder cancer incidence rate of up to 25%; (2) gallbladder stones more than 3cm, even if there are no obvious symptoms should also be actively treated, because of the stone more than 3cm of gallbladder stone patients, the incidence of gallbladder cancer is significantly higher than the stone is less than 3cm people; (3) asymptomatic gallbladder stones combined with gallbladder polyps 4, Patients with diabetes mellitus combined with gallbladder stones should be operated as soon as possible once clinical symptoms appear, and there is even a view that they should be operated even if they are asymptomatic. 5, Cirrhosis portal hypertension complicating gallbladder stone incidence is 4-5 times higher than normal, although cirrhotic patients are not a contraindication to LC, but belong to the difficult LC surgery, because of portal hypertension around the gallbladder and the triangular area of the gallbladder is rich in blood vessels, easy to bleed, easy to adhesion, the operation should be careful. 6, chronic cholecystitis and stone acute attack patients, most of the antispasmodic, analgesic, anti-inflammatory treatment, acute biliary colic clinical symptoms and signs can be rapidly relieved, grasp the timing of the operation, the operation can be carried out: and another type of gallbladder stone incarcerated, although it has been symptomatic medication, signs and symptoms can not be relieved, the gallbladder wall is prone to necrosis, or even perforation of gallbladder to form peritonitis, the early operation of this patient! In such patients, surgery should be performed as soon as possible, and LC surgery should not be performed for more than 24 hours.