The differences between acute glomerulonephritis and nephrotic syndrome are as follows: First, the etiology is different. Acute glomerulonephritis is common after bacterial infection, especially after streptococcal infection; nephrotic syndrome is often caused by primary or secondary factors. Second, the clinical manifestations are different. The main manifestations of acute glomerulonephritis are sudden appearance of hematuria, proteinuria, edema and hypertension as well as transient renal insufficiency, but the patients are often able to gradually relieve the symptoms on their own after 8 weeks; the clinical manifestations of nephrotic syndrome are mainly large amount of proteinuria and 24-hour quantitative quantification greater than 3.5g, hypoproteinemia and plasma albumin less than 30g/L The clinical manifestations of nephrotic syndrome are mainly large amount of proteinuria and hourly quantification more than 3.5g, hypoproteinemia and plasma albumin less than 30g/L, and may be accompanied by edema and hyperlipidemia. The treatment of acute glomerulonephritis is often self-healing, and patients only need symptomatic treatment or rest. Symptomatic treatment often includes diuresis to reduce swelling and lower blood pressure; patients with nephrotic syndrome often need treatment through etiology and treatment with hormones or immunosuppressants. Fourth, the pathological types are different. The pathological type of acute nephritis is capillary glomerulonephritis, while the common pathological types of nephrotic syndrome are thylakoid proliferative glomerulonephritis, membranous nephropathy, membranoproliferative glomerulonephritis and microscopic lesion type.