There are many causes of pediatric congenital heart disease, and data shows that it may be related to infection during pregnancy, or may be related to genetics, and may also be related to the advanced age of the pregnant woman. In the first few weeks of embryonic development, pregnant women who have viral infections (rubella virus, measles virus), improper use of drugs, environmental pollution, exposure to high doses of x-rays and other radioactive substances, or nutritional or vitamin deficiencies of the mother can make the fetus’ heart develop abnormally. The development of abnormalities in the fetal heart, causing the onset of congenital heart disease in children. 2, pediatric congenital heart disease and may have a certain relationship with genetics pediatric congenital heart disease also has a certain relationship with genetics, generally the chance of giving birth to a child with congenital heart disease is about 6‰-8‰, if the pregnant woman had a child with congenital heart disease before, then the chance of giving birth to a child with congenital heart disease in another pregnancy will be much higher. Genetic studies suggest that most congenital heart disease is caused by the interaction of multiple genes and environmental factors. Therefore, pregnant women with a family history of congenital heart disease should also be reviewed more intensively during pregnancy for early detection. The causes of congenital heart disease are also related to advanced maternal age. With late marriage and late childbirth, the number of advanced maternal age is increasing especially in first-tier cities. Therefore, close prenatal checkups starting at 20 weeks of pregnancy are recommended to rule out fetal heart and other malformations. The older a pregnant woman is, the more attention she should receive.