The drug for the treatment of osteoporosis is called zoledronic acid once a year, the efficacy of this drug is relatively reliable, before the application of the following things need to be clear: 1, must check the bone density, because only after checking the bone density to clarify whether there is osteoporosis, more importantly, first check the bone density and then treatment, after 1 year to check the bone density again, in order to know whether the treatment is effective. 2, before using this drug must The kidney function and blood calcium must be checked before using this drug, low blood calcium and renal insufficiency can not be applied. The common adverse reactions to this drug are fever and extremely rare kidney function damage, so for older, particularly weak elderly people, the infusion must be discussed with the doctor first to see how much it interferes with the patient, whether the benefits are greater or the disadvantages are greater.