Glucocorticoids are the most important class of drugs in the treatment of our rheumatic immune diseases and kidney diseases. However, there are many cases of patients refusing or using hormones irregularly because they are worried about the side effects of hormones, resulting in the delay of their diseases. Therefore, it is very important to correctly understand the side effects of hormones, cooperate with doctors to prevent and control the side effects of hormones, and use the advantages of hormones to better control the disease. 1.Pharmacological effects of glucocorticoids Anti-inflammatory, immunosuppressive, anti-shock, anti-allergic. 2.Dosing methods According to different disease conditions, hormone administration methods and time of administration are different: (1) High-dose shock therapy: Applicable to autoimmune diseases or certain kidney diseases with high activity, which need to actively control the disease, otherwise it can bring irreversible organ damage and even life-threatening consequences. (2) General dose long-term therapy: for most immune diseases and kidney disease long-term use of methods to control disease relapse. (3) Small-dose replacement therapy: used for the treatment of disease control but the level of hormone secretion decreases. 3. Glucocorticoid side effects and preventive measures: (1) Common side effects of pharmacological hyperadrenocorticism Glucose metabolism abnormalities: hyperglycemia, diabetes; lipid metabolism abnormalities: full-moon face, buffalo back, centripetal obesity, acne and other symptoms of Cushing’s syndrome; protein metabolism abnormalities: muscle weakness, muscle atrophy, skin whitening; water and salt metabolism abnormalities: hypertension, hypokalemia. Preventive measures: Regularly follow up with the doctor, adjust the hormone dosage according to the condition, and gradually reduce the hormone dosage after the condition is controlled. At the same time, regular biochemical and other tests should be done to detect side effects in time. Side effects can be treated symptomatically. Do not adjust the dosage of hormone or use the so-called secret formula by yourself. (2) Hormone induced and aggravated infections Preventive measures: Avoid infections and activities in places with many people and poor air circulation. Once infected, seek medical consultation and actively fight against infection under the guidance of a doctor. (3) Hormone-induced and aggravated peptic ulcers Preventive measures: Take gastric mucosal protective agents. (4) Hormone-induced osteoporosis and femoral head necrosis Preventive measures: osteoporosis is related to the dose and duration of hormone use. During the use of hormones, calcium and active vitamin D can be supplemented appropriately to prevent osteoporosis and osteonecrosis of the femoral head. (5) Growth retardation caused by hormones Preventive measures: Regular follow-up, early reduction of medication for stable condition. 4.Harm of private discontinuation Sudden discontinuation of long-term glucocorticosteroids may cause relapse or aggravation of the disease, which may lead to the need to increase the dose again and increase the side effects. Therefore, withdrawal and reduction of hormones must be done under the guidance of doctors. Our rheumatology and immunology nephrology department has rich experience in the use of hormones, and we also combine the characteristics of Chinese medicine, using Chinese medicine to have certain advantages in reducing the infection rate and side effects such as femoral head necrosis in patients who use hormones for a long time.