The occurrence of osteoporosis is closely related to changes in hormonal regulation (mainly estrogen, parathyroid hormone, calcitonin and active vitamin D,), nutritional status (calcium, phosphorus, protein and fat, etc.), physical factors (exercise, sunlight), immune function and genetics. The main causes of bone pain can be summarized as follows: ① in the process of bone transformation, increased bone resorption, destruction of bone trabeculae, destruction of subperiosteal cortical bone and osteolysis of osteoclasts, with nocturnal pain as the main manifestation; ② microfractures caused by mechanical stress, with pain after exertion as the main manifestation; ③ skeletal deformities caused by muscle (3) abnormal force on muscles, ligaments, and lumbar back muscles during the activities of osteoporotic patients, resulting in fatigue and spasm of the lumbar back plate muscles; (4) severe low bone mass failure, caused by long-term bed rest and braking; (5) fragility fractures, which usually appear after minor trauma. The possible reasons for the lower number of men than women among patients with bone pain are: (1) Men have a higher pain threshold, and the education and character development of men make them reluctant to express pain, as well as less concern for themselves than women, resulting in a lower proportion of visits to the doctor for pain. (2) Men originally have a lower rate of osteoporosis than women.