As children’s body functions are not well developed, sometimes fever is accompanied by cold hands and feet, so parents tend to ignore the problem. The following is a brief introduction to the causes of cold hands and feet in children with fever. The body temperature is regulated by the hypothalamus temperature center, if there is inflammation in the body, the temperature center will raise the temperature set point, the purpose is to improve immunity, inhibit pathogenic bacteria, when the child has a fever, peripheral vascular constriction, circulation is not good, so the child’s hands and feet feel cold. Children with fever often have cold hands and feet, but in fact it is a physiological phenomenon of false cold and true heat. Although the child’s hands and feet are cold, but the body temperature is increased. When children have a fever, their hands and feet are cold, and when the fever subsides, their hands and feet will slowly heat up again. This physiological phenomenon is common in children under 3 years of age. In addition, children’s nervous system is not yet mature, and the plant nerves, which control the diastolic contraction of blood vessels, are prone to disorders, resulting in spasmodic contraction of capillaries at the ends of the limbs after a fever, which leads to cold hands and feet. Through the introduction, we understand that cold hands and feet in children with fever is a normal phenomenon, do not panic. After a child has a fever, we should let him drink more water and eat more fruits and vegetables to enhance the body’s immunity.