To understand the risks of immunosuppressive therapy, one needs to know the role of the immune system. The role of the immune system: 1. Recognition of microbial infections: such as bacteria, viruses, fungi, parasites, etc. The body’s immune system recognizes these sources of infection and produces antibodies that stick to these pathogens, in attracting phagocytes to kill them. 2, recognition of foreign molecules (antigens) that have not been in contact with the body and reject them (causing killing, inflammation, etc.) It is clear how important the human immune system is to us. However, in the nephritis attack is precisely the killing response of the human immune system to attack itself, what to do, at this time, we are compelled and need to suppress this killing response and reduce self damage. From this, as you can imagine, this is when the body’s resistance is significantly reduced and vulnerable to microbial invasion. This is the risk!!! , and not only that, the infection at this time, in turn, tends to aggravate the nephritis damage! Adding insult to injury.