If noninvasive DNA is high-risk, there is some chance of a normal pregnancy undergoing amniocentesis, but most of them are problematic. Non-invasive DNA (deoxyribonucleic acid), the full name is non-invasive DNA prenatal testing, also known as non-invasive prenatal DNA testing, is a selection of maternal plasma fetal free DNA to detect the means; if the chromosomal abnormality of the fetus, it will lead to the mother’s DNA content will also occur in small quantities of changes, non-invasive DNA testing is the use of deep sequencing, as well as bioinformation can be analyzed and detected this change Non-invasive DNA testing can analyze and detect such changes with the help of deep sequencing and biological information. Non-invasive DNA suggests a high risk and requires further amniocentesis for a clear diagnosis; non-invasive DNA can only check 3 pairs of chromosomes, while amniocentesis can check all chromosomes, so amniocentesis is the gold standard for diagnosing chromosomal disorders. In addition, if a pregnant woman who has undergone non-invasive DNA shows a high risk, it is recommended that she undergoes amniocentesis as prescribed by her doctor for a definitive diagnosis.