Clinical breast nodules are more common in benign cases, often with clear borders to surrounding tissues, smooth and pushable nodule surfaces, and usually not serious. Malignant lesions are rare. These nodules do not have clear borders with the surrounding tissue, and their surfaces are not smooth and irregular. Once a malignant nodule is present, it usually indicates a more serious condition and requires corresponding surgical removal followed by systemic treatment. Common benign changes include mastocytosis, breast fibroadenoma, and simple cysts of the breast, etc. Some patients may even disappear without treatment of the nodules. Some patients require medication or surgery, and the prognosis is usually good and does not affect the patient’s life expectancy. Malignant breast nodules are usually breast cancer or cancer cells from other cancers that have metastasized to the breast, and these patients usually have no obvious clinical symptoms in the early stage, so they are usually in a more serious condition and have a poorer prognosis when they are seen. Treatment is usually based on surgery, and some patients may also need chemotherapy, radiotherapy, targeted therapy and other systemic treatments after surgery. If a nodule is found in the breast, early consultation is beneficial in controlling the disease. Imaging tests such as ultrasound can usually be performed to clearly visualize the nodules, and if the situation requires, ultrasound-guided puncture biopsy can be done to clarify the pathology of the nodules.