Liver cancer is one of the most common malignant tumors in China, and its death rate ranks second among malignant tumors and has jumped to the first place in some areas with high incidence of liver cancer. The annual number of liver cancer deaths in China reaches 130,000, accounting for about 53% of the deaths from liver cancer worldwide. Clinically, 90%-95% of liver cancer patients occur on the basis of viral hepatitis B and C and liver cirrhosis. How to prevent the occurrence of hepatocellular carcinoma? 1.Strengthen medical treatment: especially antiviral treatment, which is currently found to reduce the risk of liver cancer; 2.Patients with cirrhosis: if there is hypersplenism, which causes significant reduction of white blood cells, it is also recommended to remove the spleen to improve the immune status of the body to reduce the risk of liver cancer; 3.Maintain an optimistic state of mind and a good life routine. 2. How to detect liver cancer at an early stage? 1. Patients with chronic hepatitis B and C: it is better to have ultrasound examination and fetoprotein screening once every six months or so; 2. Patients with cirrhosis should have shorter examination time: it is better to have screening once every three months or so, and they should be more alert when cirrhosis has obvious nodules; 3. 3. How to choose the best treatment when liver cancer has already occurred? At present, the treatment of liver cancer emphasizes comprehensive treatment on the basis of surgical resection to improve patients’ quality of life and prolong survival time. Surgical resection is still the preferred method and the most effective measure to treat liver cancer. The treatment of liver cancer should follow the following principles: 1. Early detection and early treatment: early and effective treatment is the most important aspect to improve the efficacy of liver cancer. 2.When the diameter of liver cancer mass is ≤5cm: surgery is preferred. Surgery can achieve the effect of radical cure, and combined with postoperative interventions and other treatments, it can improve the cure rate and reduce the recurrence rate. 3.When the diameter of liver cancer mass is >5cm or multiple masses: depending on the specific situation, surgical resection, or interventional mass reduction before resection, surgical resection combined with radiofrequency ablation treatment can achieve more satisfactory curative effect or even radical cure. 4.Positive treatment attitude should be adopted in treating liver cancer: do not give up easily, sometimes repeated treatment is needed, for example, resection of recurrent tumor after surgery and multiple interventions can achieve more satisfactory results.