IgA nephropathy Oxford staging pathology staging report form
Contents include 4 pathological indicators that independently affect prognosis.
Thylakoid cell hyperplasia (M0/1)
Endothelial cell hyperplasia (E0/1)
Segmental sclerosis or adhesions (S0/1)
tubular atrophy or interstitial renal fibrosis (T0/1/2)
Pathological indicators
Definition
Integral
Thylakoid proliferation score (M)
<4< span=""> thylakoid cells/ thylakoid area = 0
M0: ≤0.5
4-5 thylakoid cells/ thylakoid zone = 1
M1: >0.5
6-7 thylakoid cells/ thylakoid region = 2
>8 thylakoid cells/ thylakoid zone = 3
Thylakoid cell proliferation score was averaged over all glomeruli
Intracapillary proliferative lesions (E)
Glomerular intracapillary cell proliferation causing collateral lumen narrowing
E0: no
E1: yes
Segmental sclerosis with adhesions (S)
Any varying degree of collaterals involvement
S0: no
S1: Yes
Interstitial fibrosis or tubular atrophy (T)
Renal cortical tubular atrophy or interstitial fibrosis
T0: 0%-25%
T1: 26%-50%
T2: >50%
At the same time, to reflect the acute and chronic renal lesions, the number of glomeruli and some quantitative pathological indicators including the proportion of cellular or cellular fibrous crescent, the proportion of fibrinoid necrosis, the proportion of endothelial cell proliferation and the proportion of glomerulosclerosis must be issued as additional reports.