The typical clinical manifestations of anal fissure patients include pain, constipation and blood in the stool. 1.Pain: Anal fissure can cause periodic pain due to fecal discharge, which is the main symptom of anal fissure. When defecating, the nerve endings of the ulcer surface are stimulated by the fecal mass, and the burning pain in the anus is felt immediately, but the pain is relieved a few minutes after defecation. Later, due to the spasm of the internal sphincter, severe pain is produced again, and this period can last for half an hour to several hours, making the patient restless and difficult to bear, until the sphincter is fatigued, the muscle relaxes and the pain is relieved. However, the pain occurs again when the patient defecates again. The above clinical term is anal fissure pain cycle. The pain may also radiate to the perineum, buttocks, inner thighs or sacrococcygeal region. Wang Hao, Department of Anorectal Medicine, Guangdong Provincial Hospital 2, constipation: This is the cause of anal fissure and the consequence of anal fissure. After the anal fissure, patients are reluctant to defecate because of anal pain, which over time causes constipation, dry and hard stool, and constipation can aggravate the anal fissure, forming a vicious circle, making it difficult to heal the anal fissure. 3, blood in the stool: defecation is often seen on the surface of the stool or stool paper with a small amount of fresh blood, or drops of fresh blood. Hemorrhage is rare. 4.Other: such as anal itching, secretion, diarrhea, etc. It is due to the stimulation of secretions from anal fissure ulcers or the secretions produced by complications such as anal saphenitis and anal papillitis, which cause anal itching.