Membranoproliferative glomerulonephritis, also known as thylakoid capillary glomerulonephritis, is a more severe type of pathology in the nephrotic syndrome. Typical pathologic changes are diffuse glomerular thylakoid cell proliferation, thickening of capillary collaterals and double-tracking changes of the basement membrane, with insertion of proliferating thylakoid stroma between the endothelium and basement membrane and formation of basement membrane double-tracking. Membranoproliferative glomerulonephritis is commonly seen in adolescents and children without gender differences. clinical manifestations include nephrotic syndrome, acute nephritis syndrome, asymptomatic proteinuria and hematuria and recurrent carnitic hematuria, most with a history of antecedent respiratory infection. 1/3 of patients have combined hypertension and renal insufficiency occurs in more than 50% of patients, often with hypocomplementemia. The clinical response to hormonal and immunological agents is relatively poor, and the prognosis is poor.