Self-healing of IgA nephropathy is limited to some patients with very mild disease. IgA nephropathy starts mostly due to infections, such as upper respiratory tract infections, gastrointestinal, pulmonary and urinary tract infections. 24 to 72 hours after infection, sudden haematuria visible to the naked eye may appear and last for a few hours or days, then disappear or transform into microscopic haematuria, requiring a renal puncture biopsy for diagnosis.
In some patients who present with only simple haematuria and mild proteinuria. If the kidney function is normal, no specific treatment is needed. Avoiding strain, preventing colds and flu, avoiding nephrotoxic drugs and regular review are all that is needed. However, in most cases, the kidney is more severely diseased and should be treated aggressively with a combination of medications and relapse prevention.