Antibiotics are routinely used in the treatment of acne and are divided into two categories: topical and internal, which can control the reproduction of Propionibacterium acnes and reduce inflammation, mainly including the following: 1. Topical antibiotics: usually used for patients with mild acne, including topical preparations such as fusidic acid cream, erythromycin ointment, lincomycin, clindamycin, and chloramphenicol; 2. Oral antibiotics are one of the effective methods for the treatment of moderate to severe acne, including erythromycin, doxycycline, minocycline, etc. It is recommended that pathogenic microorganism culture and drug sensitivity tests be conducted before taking them to determine the appropriate antibiotics. In addition, it should be noted that doxycycline should be used with caution in patients with hepatic insufficiency, and erythromycin has mutual antagonism with chloramphenicol and lincomycin drugs, so avoid combining them. Azithromycin should be used with caution in patients with hepatic and renal insufficiency, pregnant and lactating women, patients with cardiac insufficiency and patients with cardiac arrhythmia. Also, you should pay attention to cleanliness in your daily life, wash your face regularly, keep your skin dry, and avoid using oil and phenolic cosmetics as much as possible.