In infancy, especially in infancy, the mucosal immune system is affected by innate factors (including the maternal environment during the embryonic period) and the passive use of antimicrobials later in life, and the fragile intestinal microecosystem is easily disrupted, bringing about various pathologies following mucosal immune dysregulation, mainly recurrent respiratory syndrome and food allergy, due to the “recurrent respiratory infections The prevalent use of multiple antimicrobials for “recurrent respiratory infections”. The immune anatomy underlying the occurrence of this condition is the mucosal immune system, and once abnormal, recovery time takes at least 3 to 6 months. Unfortunately, in such cases, many children are diagnosed with various “respiratory inflammatory conditions” and are constantly on antimicrobials; many allergies are thought of by the parents; and many parents of children “run” between respiratory medicine, internal medicine, ENT, and even dermatology and child health for long periods of time “. Some of them abuse various “immunomodulatory” drugs to “increase immunity” during frequent treatment. When dealing with such cases, patients often think about what drugs to use and how to administer them. For example, hormonal sprays and inhalants, and prolonged use of an antimicrobial agent because it seems to have “immunomodulatory and anti-inflammatory” effects, while ignoring the fact that it is an antimicrobial agent in the first place, and that the advantages and disadvantages must be weighed before use, without neglecting the normal flora (the commensal group of human respiratory and digestive tracts) that is so important for the mucosal immune system. for the maintenance of the respiratory barrier and the normal immune response balance. A very important condition should not be ignored – the potential allergens and pathogens in the indoor environment Often, people are more concerned about outdoor air quality and the indoor environment is mostly ignored. When parents have done and maintained the indoor environment as required, they have found that the frequency and extent of their children’s illnesses can be partially improved. These parents found that “dust” was evident on the tops, backs and bottoms of furniture, and on curtains. Dunnets (mops used to wipe floors) that have not been dried for a long time are also media for spreading pathogens. These can be changed by wiping with water or washing and drying. Bedding cleaning is even more important, especially for children who are allergic to household dust mites, it is not too much to change items above the bed sheet (including sheets) every day (pillowcases, duvet covers and sheets should all be taken outdoors for at least one hour before washing). A very important habit and dietary condition should not be neglected either – brushing/rinsing with water and eating lightly First of all, brushing and rinsing really do not eliminate bacteria in the mouth, but remove food debris. The latter can lead to unhealthy chemical and biological effects in crevices and crypt foci, resulting in persistent chemical irritation and bacterial enhancement. Secondly, a light diet is very important for children with mucosal immune-related respiratory syndrome. However, the control of ionic concentrations involved in dietary habits is neglected. For example, salt (sodium chloride), desserts (osmotic), and acid diet (hydrogen ion concentration) all produce stimulation of the mucosa (especially in the common zone of the laryngeal mucosa), leading to direct mucosal damage or proliferation of submucosal lymph-like cells (mucosa-associated lymphoid tissue) and increased secretion of mucosal cells, producing corresponding symptoms and abnormal immune response effects. This local effect is very pronounced in patients with adenomatous hypertrophy (palatine tonsils and adenoid hypertrophy), and the abnormal immune response effect also triggers an enhanced airway response. Parents, paying attention to this will lead to better outcomes for your child during the course of comprehensive treatment. Since it takes at least 8 to 12 weeks (or even 6 months) for mucosal immunity to return to homeostasis, please be persistent. Do not rely solely on controller medications, be cautious about using saline-based cleansing of the nasopharyngeal cavity, and reduce the frequency of antimicrobial use in the absence of fever, even those that seem to have immunomodulatory effects. Avoid the vicious circle formed by multiple dysbiosis leading to mucosal immune barrier damage.