Second-line endocrine therapy is an endocrine treatment regimen used for hormone-non-dependent prostate cancer and consists of the following: 1. For patients treated with single depot therapy, add an anti-androgen drug. 2. For patients treated with combined androgen blockade therapy, discontinue the anti-androgen drugs. 3.A few patients can benefit from interchangeable anti-androgen drugs. 4.Adrenal androgen inhibitors. 5.Low doses of estradiol and megestrol.