I always encounter many patients asking me this question: “Among the many treatment methods for liver cancer, which one should I choose, surgical resection, radiofrequency, intervention, or even transplantation?” Today, I would like to briefly explain this question again: liver cancer is the most common malignant tumor in liver, with a high degree of malignancy and a median survival time of about 6 months without treatment. There are many treatment methods for liver cancer, such as liver resection, liver transplantation, chemoembolization of liver cancer via hepatic artery, radiofrequency ablation, microwave ablation, anhydrous alcohol injection, radiotherapy, chemotherapy, etc. 1.Chemotherapy and radiotherapy have low efficacy and high toxic side effects, so they cannot be used as the first-line treatment methods. The efficiency of this method can reach 80%, but the blocked artery is easy to be reopened due to the opening of collateral circulation, and the tumor will revive, so the 5-year survival rate of patients through interventional treatment is only 10%. However, this method is often used to reduce the size of the tumor and lower the stage, so as to create conditions for surgical ablation treatment. In 2015, an article published in the International Journal of Hepatobiliary and Pancreatic Surgery summarized that 7 doctors selected more than 1,000 patients for liver resection and radiofrequency ablation strictly in accordance with tumor diameter ≤3cm, and the 5-year survival rate of liver resection was more than 50%. The 5-year survival rate of liver resection was more than 50%, while the survival rate of radiofrequency ablation was only 30%. The difference in efficacy between the two is very large. The efficacy of microwave ablation and radiofrequency ablation is more similar. 4.Liver transplantation can remove the tumor together with the diseased liver, which can remove both the primary foci and metastases and sclerotic liver, so it is theoretically the most effective method and can bring long-term cure to patients. 5.Hepatectomy for liver cancer has a history of over 100 years and is the most mature method for treating liver cancer. It has undergone the evolution from regular resection to partial resection and then to anatomical liver segment resection. Early regular resection is the removal of the left or right half of the liver, as patients with liver cancer often have a background of cirrhosis, and extensive liver resection carries the risk of liver failure. Local resection is the removal of the tumor along 1 cm of the tumor periphery, which is a relatively simple and safe procedure, but may result in residual metastatic subfoci and easy recurrence after surgery. Couinoid, a French scholar, divided the liver into eight segments according to the branches of portal vein blood supply, and each liver segment is an independent functional unit that can be resected independently or combined —- anatomical hepatic segmental resection, which is currently the first internationally accepted method for hepatic resection of liver cancer. How to achieve precise hepatic segment resection has been the goal I have been pursuing for many years, and it has been affirmed by peer experts in the industry and patients, because only such hepatic resection surgery can maximize the removal of tumor while maximizing the retention of remaining liver volume and functional integrity. Both the primary foci and metastases can be removed, and the recurrence rate will be reduced after surgery, and the long-term survival rate will be greatly improved. It should be said that each method has its own advantages and disadvantages. As a doctor, you should master each method and make the most reasonable individualized treatment plan according to the different conditions of each patient!