At present, there are three main criteria for the selection of liver transplantation indications for liver cancer abroad: Milan criteria [[i]]: proposed by Mazzaferro, an Italian scholar in 1996, namely, a single tumor ≤ 5 cm in diameter or a number of multiple tumors ≤ 3, and a maximum diameter ≤ 3 cm. Pittsburg modified TN M criteria [[ii]]: proposed in 2000, only the presence of large blood vessels In 2000, it was proposed that only the presence of any one of the three criteria: large vessel invasion, lymph node involvement or distant metastasis is a contraindication to liver transplantation, and the size, number and distribution of tumors are not considered as exclusion criteria. UCSF criteria [[iii]]: In 2001, Yao et al. at the University of California, San Francisco proposed that a single tumor diameter ≤ 6.5 cm, or the number of multiple tumors ≤ 3 and each tumor diameter ≤ 4.5 cm, and the total diameter of all tumors ≤ 8 cm. Both Milan and UCSF criteria considered the size and number of tumors, while the prognosis was closely related to the background of liver disease, tumor vascular invasion and lymph node metastasis. The Pittsburgh modified TNM criteria are not easy to accurately determine whether the tumor is metastatic and invades the blood vessels before surgery, so they are not widely accepted and used. Domestic liver cancer liver transplantation indications selection criteria and evaluation More than 85% of liver cancers in China are combined with varying degrees of viral hepatitis cirrhosis, combined with the actual situation in China, several large transplantation centers in China have proposed different criteria based on their own experience: Shanghai Fudan criteria [[iv]]: single tumor diameter ≤ 9 cm, or multiple tumors ≤ 3 and the largest tumor diameter ≤ 5 cm, the total diameter of all tumors ≤ 9 cm No large blood vessel invasion, lymph node metastasis and extra-hepatic metastasis. Hangzhou standard [[v]]: Patients without portal vein cancer thrombosis, tumor diameter <8 cm, methemoglobin level <400 ng/L and histological grading of high and moderate differentiation are preferred for liver transplantation; if tumor diameter >8 cm, methemoglobin level <400 ng/L and histological grading of high and moderate differentiation must be met before liver transplantation can be considered. Huaxi criteria [[vi]]: (1) small hepatocellular carcinoma and still resectable hepatocellular carcinoma with severe cirrhosis or hepatic insufficiency; (2) large unresectable hepatocellular carcinoma without main portal vein thrombosis or distant metastasis yet; (3) those with main portal vein thrombosis should be used as counter indications for liver transplantation. The three domestic criteria for selecting indications for liver transplantation for hepatocellular carcinoma are different, and the general principle is that the tumor size is appropriately relaxed, but the absence of vascular invasion and distant metastasis is emphasized, and the degree of tumor differentiation in Hangzhou criteria is not easily determined preoperatively. The surgical efficacy according to the domestic criteria is close to the more stringent Milan, while the surgical indications are relaxed, which can allow more liver cancer patients to have the opportunity to receive liver transplantation treatment.