1.The following conditions are prohibited: bronchial asthma, cardiogenic shock, heart block (second and third degree conduction block), severe or acute heart failure, sinus bradycardia. 2. Reduce or discontinue the use of the following conditions: congestive heart failure, emphysema, non-allergic bronchial asthma, pulmonary insufficiency, renal failure. 3.Go to local hospital to test heart rate, respiration, blood pressure and blood glucose twice a week, if heart rate is less than 100 beats/min, etc. Seek medical attention in time. 4. Pay attention to reasonable feeding, strengthen nutrition, and take medication on time and in the right dosage every day, and take medication after meals. Do not change the dosage of medication on your own. 5.Follow up on Thursday after 1 month, if there is any discomfort, follow up.