There are many pathogenic microorganisms that cause subacute infective endocarditis, among which Streptococcus straw green is the most common, in second place are group D streptococci, including Streptococcus bovis and Enterococcus, others such as Staphylococcus epidermidis and fungi, rickettsia and Chlamydia are present but relatively uncommon. The main site of subacute infective endocarditis is the aortic valve, while other valves are relatively uncommon, probably related to the richer amount of blood flow in the aortic valve area. Because the endocardium is a necessary part of the blood flow through the heart, once the endocardium becomes infected, it can cause infection throughout the body’s circulation and can easily lead to diseases such as sepsis, which, if left untreated, may lead to life-threatening heart failure in a short time.