Most patients with autoimmune diseases require long-term or even lifelong medication, so it is important to master the correct medication regimen according to the characteristics of the drugs. The physiological functions of human body usually have certain periodic changes, and various physiological indicators of the body have obvious rhythmic fluctuations during the day, such as body temperature, blood pressure and blood sugar. The absorption, distribution, metabolism and excretion processes of many drugs in the body also show obvious circadian rhythmic changes, thus affecting the efficacy and toxicity of drugs. If the same drug is taken at different times of the day, the efficacy and toxicity may vary several times. Therefore, it is important to consider a reasonable time of administration to achieve maximum efficacy and minimum toxicity. The following is a list of the rules for the administration of drugs commonly used in patients with autoimmune diseases for your reference. Glucocorticosteroids (such as prednisone acetate, prednisolone acetate, methylprednisolone, etc.): The secretion rhythm of glucocorticosteroids shows circadian rhythmic changes, with the peak blood concentration generally at 7-8 am and the trough value at 0 midnight. Therefore, it is best to take hormonal drugs in the morning, so glucocorticoids are chosen to be administered at 7-8 am. NSAIDs (e.g., Nimesulide, Loxoprofen sodium tablets, Fotarolim, Meloxicam, etc.): A study at Texas Tech University found that arthritis patients were sickest in the afternoon. Therefore the best time to take NSAIDs is from noon to afternoon. In addition, the study also found that arthritis such as rheumatoid arthritis is most severe in the morning, and these patients are best served with medication after dinner. Anti-osteoporosis drugs: Calcium: The body’s blood calcium level is lowest between midnight and early morning. Therefore, calcium supplements taken before bedtime can enable adequate absorption and utilization of calcium. Alendronate (such as alendronate sodium vitamin D3 tablets): because this type of drug food affects its absorption, so the best effect when taken on an empty stomach, and such as Fumagal and other drugs, water delivered on an empty stomach, should not lie down within half an hour, should remain in an upright position to prevent drug stimulation of the esophagus and other locations. Digestive system drugs: In order to better play the drug effect, most of them are taken before meals. Such as gastric acid inhibitors: omeprazole enteric capsules, pantoprazole enteric capsules; gastric mucosa protectors such as magnesium aluminum carbonate tablets, aluminum thioglycollate, colloidal bismuth; gastrointestinal motility drugs: domperidone, metoclopramide, mosapride; gastrointestinal antispasmodics such as bromoproterenol, belladonna combination; digestive drugs such as multi-enzyme tablets, lactobacillus, etc. Blood pressure drugs: According to the rhythm of the human biological clock, if blood pressure drugs are taken once a day, it is appropriate to take them in the morning for better efficacy; if blood pressure drugs are taken three times a day, it is appropriate to take them at 7:00 a.m., 3:00 p.m. and 7:00 p.m. respectively. It is not advisable to take antihypertensive drugs at night before going to bed to prevent low blood pressure and bradycardia, resulting in cerebral thrombosis. Antidepressants: Because depression is characterized by lightness in the evening and heaviness in the morning, the 5-hydroxytryptamine reuptake inhibitors fluoxetine and paroxetine should be taken in the early morning. Fibromyalgia syndrome patients commonly used anti-anxiety drug flupirtine melitrexin tablets (Dextran), has a mild excitatory effect, should also be taken in the morning.