Causes and management of primary liver cancer with hypoglycemia

Hypoglycemia and symptoms: Fasting blood glucose concentration below 2.8 mmol/L in adults is called hypoglycemia, and it is when blood glucose falls below a much lower level that it leads to the appearance of some symptoms – hypoglycemia. Hypoglycemia means: blood sugar is lower than a specific level and leads to the appearance of a series of symptoms, and the diagnostic criteria are: <50mg/dl (<2.78mmol/L) for men and <40mg/dl (<2.5mmol/L) for women (normal male after 72 hours of starvation, lowest value for women), when the blood sugar concentration is lower than 50~60mg/dl, early symptoms of hypoglycemia appear (limbs When the blood glucose concentration is lower than 50~60mg/dl, the early symptoms of hypoglycemia will appear (cold limbs, pale face, cold sweat, dizziness, panic, nausea, etc.); when the blood glucose concentration is lower than 45mg/dl, the late symptoms of hypoglycemia will appear (in addition to early symptoms, convulsions and coma, etc.). Hypoglycemia is divided into two types: 1. Adrenergic symptoms include sweating, nervousness, trembling, weakness, vertigo, palpitations, hunger, attributed to increased sympathetic nerve activity and increased adrenaline release (can occur in patients with adrenalectomy). 2. Central nervous system manifestations include confusion, abnormal behavior (which can be mistaken for intoxication), visual disturbances, xerostomia, coma, and seizures. Hypoglycemic coma is often associated with a decrease in body temperature. The rate of blood glucose reduction is faster in sympathetic symptoms than in central symptoms, but the degree of hypoglycemia is mild, and there are significant individual differences in blood glucose levels in either type. Liver cancer and hypoglycemia causes As a malignant tumor disease, liver cancer is caused by many reasons, among which lifestyle is also one of the important reasons for liver cancer. Here we hope that we can maintain a healthy lifestyle and positive attitude to prevent the occurrence of liver cancer. In clinical practice, about 10%~30% of patients may experience spontaneous hypoglycemia of different degrees, which commonly manifests as dizziness, panic, cold sweat, blackness in front of the eyes, etc. Serious cases may lead to coma, shock or even death. Hypoglycemia is a common paraneoplastic syndrome of hepatocellular carcinoma, the cause of which is still unclear, and the reasons why it is prone to hypoglycemic symptoms are as follows: 1. Liver patients have reduced appetite, digestion and absorption dysfunction, resulting in insufficient glucose intake. 2.Liver tumors lack glycogenolytic enzymes, and the efficiency of glucose conversion into energy is low. 3, Liver cancer cells secrete insulin or insulin-like substances, or secrete an islet beta-cell stimulating factor, which are capable of lowering blood glucose. 4.Because hepatocytes need to metabolize glucose for survival or proliferation, plus the glycogen reserve of residual liver tissue is insufficient, and liver cancer is able to consume a large amount of glucose when it is huge (50-200 grams of glucose per kilogram of liver cancer per day). 5. The cancer tumor compresses the unknown receptors of the peritoneum and prevents the excitation of sympathetic nerves to the liver, which cannot activate glycogen and buffer blood sugar level effectively. First-aid measures for hypoglycemia: 1. Bed rest and rapid glucose supplementation are the key to determine the prognosis. Timely glucose replenishment will lead to complete relief of symptoms; while delayed treatment will result in irreversible brain damage. Therefore, immediate administration of any substance with high sugar content, such as cookies and fruit juice, should be emphasized at the time of hypoglycemic attack. 2.Patients with hypoglycemia who can eat by themselves, the diet should be low in sugar, high in protein and fat, with few meals and more meals, and add sugar material once at midnight if necessary. 3.Intravenous injection of 50% glucose 40-60ml is the most common and effective method to rescue hypoglycemia. If the condition is not serious and has not caused serious brain function damage, the symptoms can be relieved quickly and the mind can be awake immediately. Patients with conditions should be measured immediately by blood glucose meter, and those whose blood glucose is less than 3.8 mmol/l should be quickly supplemented with carbohydrate-containing food, such as half cup of sweet juice, half cup of sugar water, 1 tablespoon of honey, 3-5 cookies, 2-3 candies, etc. After 10-15 minutes, if the symptoms have not disappeared, they can eat again. If the symptoms disappear but there is still more than 1 hour before the next meal, add a staple food such as 1 slice of bread, a steamed bun, 3 to 5 cookies, etc. If confusion or sudden coma occurs, family members should send the patient to hospital as early as possible. Diet for advanced hypoglycemia in liver cancer: 1. Diet for advanced hypoglycemia in liver cancer should be balanced and contain at least 50-60% carbohydrates (the same dietary principles as diabetic patients), including vegetables, brown rice, avocado, konjac, seeds, drupes, cereals, lean meat, fish, yogurt and raw cheese. 2. A high-fiber diet helps stabilize blood sugar levels. When blood sugar drops, combine fiber with protein foods (for example, bran cakes with raw cheese or almond jam). Eat fresh apples instead of applesauce. The fiber in apples can suppress blood sugar fluctuations and raise blood sugar concentration. 3.Eat both meat and vegetables, and reasonably match meals to ensure the intake of comprehensive and sufficient nutrients, so that the physique gradually becomes robust from frail. 4.If the anemia is accompanied by low red blood cell count and insufficient hemoglobin, it is appropriate to eat more foods rich in protein, iron, copper, folic acid, vitamin B12, vitamin C and other "hematopoietic materials", such as pig liver, egg yolk, lean meat, milk, fish and shrimp, shellfish, soybeans, tofu, brown sugar and fresh vegetables and fruits. Correcting anemia is good for increasing cardiac blood output, improving blood supply to the brain, raising blood pressure and eliminating the adverse symptoms caused by low blood pressure. 5.Fruits such as lotus seeds, cinnamon, jujube and mulberry, which have the power to nourish the heart and blood, strengthen the spleen and nourish the brain, can be consumed frequently. Treatment principles: treatment of liver cancer lesions (clinical surgery, intervention, microwave, etc.)