Osteosarcoma is a malignant tumor of mesenchymal origin with the ability of tumor cells to form bone or tumor-like bone. 2002 WHO Classification of Tumors of Bone and Soft Tissue classically defines osteosarcoma as a highly malignant spindle-shaped cell that produces bone-like bone. Prior to the 1970s, amputation was the main method of surgical treatment for osteosarcoma, but after the 1980s, with the development of neoadjuvant chemotherapy and advances in surgical techniques, limb preservation techniques have made great progress. Currently, limb preservation has become the main development direction of surgical treatment for osteosarcoma of the limb. According to statistics, less than 10% of the current treatment methods for osteosarcoma of the limb are amputation and more than 90% are limb preservation, which has achieved a similar survival rate as amputation and has not led to an increase in the local recurrence rate.