1.What kind of people should receive routine liver cancer screening? People who are at high risk for liver cancer should be routinely screened. (9) Patients with cirrhosis due to α1 antichymotrypsin deficiency; (10) Patients with other cirrhotic liver cancers. Common screening methods include serum tumor marker AFP and ultrasonography, which should be performed at least once every six months. 2.Does liver cancer run in families? Shanghai Medical University has conducted a comprehensive study on the relationship between liver cancer and heredity in Qidong area, and investigated the “second line”, “third generation”, “third cousin” and “third table” of liver cancer patients. “It was found that 42.45% of liver cancer patients had more than 2 members in their family. However, in terms of chromosomal aberrations, there was no significant difference in the rate of chromosomal aberrations between families with a high incidence of liver cancer and those with a non-high incidence. Epidemiological survey also found that these families also have hepatitis clustering phenomenon, therefore, liver cancer may have certain family clustering and their family members may also have certain tumor susceptibility, but there is no definite evidence that liver cancer is hereditary. 3.How to prevent liver cancer? Prevention of hepatitis B and C infection is the main prevention means for primary liver cancer. Hepatitis B is mainly transmitted through mother-to-child, blood, sexual contact and close contact. Mothers with hepatitis B should have their babies injected with immunoglobulin after delivery. Relatives of hepatitis B patients should have their blood tested for hepatitis and should be vaccinated with hepatitis B vaccine to effectively prevent hepatitis and liver cancer. 80%-90% of hepatitis C is transmitted through blood and blood products. Therefore, strict control of blood transfusion source and minimizing blood transfusion or application of blood products is another effective measure to reduce hepatitis C and control the occurrence of liver cancer. In addition, proper storage of various foods to prevent mold, no alcohol abuse and active treatment of fatty liver will all play a role in preventing liver cancer. 4.How to diagnose primary liver cancer? Diagnostic criteria of liver cancer include pathological and clinical diagnostic criteria. Diagnostic methods include serum tumor marker test, imaging examination and pathological histological examination (mainly liver tissue biopsy). Internationally, the diagnostic process of American Association for the Study of Liver Diseases is applied more often, and the distinction between the mass and the diagnostic process is made by occupancy <12="">50px. For patients with chronic liver disease background and intrahepatic nodules >25px, the clinical diagnosis can be made by combining 1-2 typical imaging examinations.