Trachoma can be treated locally and systemically with sensitive antibiotics, and ocular complications caused by trachoma can be treated surgically. Trachoma is an inflammatory disease of the conjunctiva and cornea caused by Chlamydia trachomatis infection. In the early stages of trachoma, lid conjunctival congestion, papillary hypertrophy, follicular hyperplasia, and corneal vascular opacification are manifested. In the late stages of trachoma, lesions of the lid conjunctiva degenerate into scarring, which can cause a variety of ocular complications, such as lid entropion, dry eye, ptosis, corneal ulceration, corneal clouding, lid bulb adhesions, lacrimal obstruction, and chronic lacrimal sacculitis, which can lead to blindness in severe cases. For the treatment of trachoma, levofloxacin eye drops can be given four times a day, combined with rifampin eye drops or sodium sulfacetamide eye drops three times a day, and tetracycline eye ointment or erythromycin eye ointment once at night, and topical medication needs to be continued for more than ten weeks. For acute stage or severe trachoma, systemic application of sensitive antibiotics can be used for treatment. For severe ocular complications, surgical procedures such as entropion correction, ptosis correction, lid bulb release, conjunctival flap masking, and nasal lacrimal sac anastomosis may be indicated. In conclusion, treatment of trachoma requires full and adequate doses of sensitive antibiotics, mainly topical and, if necessary, systemic medications, and surgery to treat serious ocular complications.