There was a female patient who had a cold in the spring. Symmetrical painful nodules appeared on both lower legs during the cold, lesions resembling impacted lumps and self-induced pain. When the nodules subsided, local indentation and hyperpigmentation appeared again, accompanied by fever. At first she came to me and I thought that the redness, swelling, heat and pain were definitely inflammatory. I also had a surgeon look at it and there were conflicting opinions, some thought it was dermatitis and some thought it was cellulitis. I used anti-inflammatory medication to reduce the fever and soon a new redness appeared. I reviewed the literature and had a dermatological consultation to consider the diagnosis: lipofuscinosis. This inflammation is the result of inflammation of the subcutaneous fat, and its etiology is still unknown. The pathological changes are predominantly lymphocytic infiltration. It is an abnormal immune response initiated by the body to its own adipose tissue and may be a delayed allergic reaction of the organism to certain pathogenic microorganisms, bacteria, fungi and other antigens. However, it is also considered to be an immune complex disease. It is associated with impaired fat metabolism or abnormalities in the enzymes that affect fat metabolism. Studies suggest that halogen compounds such as bromine and iodine and drugs containing quinoline, sulfonamide, antimony and alcohol can also induce this disease. I questioned the patient and learned that she had been in a bad mood for the past two years, had a poor diet, had frequent colds, and later developed this skin condition. I then considered that, in addition to other factors, mental health issues played a role in this. When people are emotionally happy, they can enhance their immunity by acting on cholinergic receptors on immune cells through acetylcholine transmitters released by the parasympathetic nervous system; they can also enhance their immunity by promoting the secretion of hypothalamic peptide hormones with by acting on peptide receptors on immune cells. Conversely, when the mood is unhappy and nervous, through the sympathetic nerve release a large number of catecholamine transmitters, acting on the immune cells on the catecholamine receptors, to reduce the body’s immunity; or through the brain-pituitary-adrenal cortex system to release glucocorticoids, causing a decrease in immunity. And low immunity can produce certain psychosomatic diseases. Pleasure and depression, different moods, can be powerful enough to influence our behavior and bring about different psychological effects. It also manifests differently in various organs of the body, either healthy or diseased. The root cause of many diseases is triggered by psychological behavior. Since I have been concerned with the psychological state of patients with psycho-psychiatric or psychosomatic disorders since 1993, I have found a large number of patients with psycho-psychiatric disorders secondary to immune system disorders. In the recent period, three men in the IT industry were seen in my department, all of whom suffered from “demyelinating disease” due to overwork and work stress. There are also a number of patients with rheumatic immune system diseases such as dry syndrome, rheumatoid arthritis and lupus erythematosus due to similar causes. For example, dry syndrome is a common autoimmune deficiency disease. 90% of patients with this disease are female, and the age of onset is roughly 30-40 years old. The cause of the disease is still unclear and may be related to autoimmunity, genetics, viral infection and other factors. It mainly attacks the exocrine glands, including the lacrimal and salivary glands, causing dry eyes and dry mouth. 80% of the patients with dry mouth syndrome have dry mouth symptoms. Dry mouth can last for more than 3 months, and cannot be relieved by drinking water, and eating dry food can be swallowed only with water. The dry mouth is more than 3 times at night. Dry eyes can also be more than 3 months, no other eye disease but a gritty feeling in the eyes, and eye drops must be used daily. Salivary gland lesions can cause symptoms such as dry mouth, multiple teeth, and mumps. Dry eyes, foreign body sensation, and less tears due to lacrimal gland attack decreases mucin secretion from the lacrimal glands, which is called ocular dryness. Dryness syndrome can exist alone. In addition, besides the symptoms of eyes and mouth there are unexplained arthralgia, fatness or persistent enlargement of salivary glands (parotid glands), and gradual appearance of dental caries or tooth loss within a few months or years. Organs outside the gland, such as the respiratory tract, digestive tract, kidneys, muscles, joints, and blood vessels, may be involved, causing a variety of clinical manifestations. It may also occur in another autoimmune disease with a clear diagnosis, such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, etc. The former is called primary dry syndrome and the latter is called secondary dry syndrome. The diagnosis should be checked for autoimmune defects and systemic systemic immune diseases. Such patients often complain of: dry mouth and dry tongue. Modern medicine believes that dry mouth and tongue are endocrine disorders and autonomic nervous disorders. Traditional medicine believes that: mania is an invisible evil, people with Yin deficiency and Qi deficiency are prone to deficiency heat, and heat tends to injure the immune system of the body. The immune system consists of many organs, glands, proteins and special white blood cells, including hormones of the lymphatic system such as thymus and bone marrow, antibodies and mental capacity. Its function is to resist bacteria, viruses, microorganisms, toxic chemicals, trauma, fractures, tumors, etc. to keep the body healthy. Smoking and drinking alcohol, insomnia, environmental pollution, and age progression can all damage the immune system. Some drugs such as adrenocorticosteroids, anti-inflammatory drugs, antidepressants, sedatives, epinephrine, insulin, and antibiotics may also have a negative impact on the immune system. In addition, mental stress, anxiety and depression caused by work stress, which reduces the number of special white blood cells and the activity of lymphocytes, may also affect the immune system. Those who suffer from dry syndrome should pay attention to drinking more water, avoid eating fried food, and also eat more carrots to supplement vitamin B, avoid dry lips, avoid staying up late, and eat regular and quantitative meals. In addition to specialist treatment, it is advisable to wear protective goggles, keep the room moist, use toothpaste with salt, rinse the mouth after meals, and treat periodontitis and oral mold in time if there is any. The normal immune system of the human body is in a flat state at ordinary times, if with any meal, it will break this balance and affect the work of the immune system. The immune system works best when a person is well-fed and well-drunk. The immune system is one of the eight major systems of the human body. There are two immune systems in the human body: one is the natural immune system and the other is the acquired immune system. The former is characterized by the fact that it does not need to have been exposed to pathogens before, and after the pathogen enters the body, the natural immune system is able to react to the immune response and basically control the pathogen and prevent it from spreading in the body; the acquired immune system is a more effective and accurate immune system, which can identify pathogens more accurately and play the immune effect more effectively, and can also help the natural immune system to control the spread of pathogens in the body. the body. The natural immune system plays a simple control role after the entry of the pathogen, the acquired immune system, which specifically identifies the pathogen and finally removes it. The immune system relies on two main “weapons” against pathogens that invade the body: antibodies and cells. Such antibodies are present in our blood and serum, as well as on the mucosal surfaces of the body’s lungs and nasal passages. When lymphocytes are activated, they are able to kill the tissue cells infected with the virus, which needs to replicate itself in the cells, so killing the tissue cells infected with the virus is tantamount to destroying the factories where the virus replicates and processes, eliminating their hiding places. On the other hand, almost all typical psychosomatic diseases have different degrees and different aspects of immune function changes, and many autoimmune diseases are typical of psychosomatic diseases. The neuroimmune mediating mechanism is that psychosocial stress stimuli, through the neuro-endocrine-immune system pathway, affect the enhancement or weakening of the immune system function, thus affecting the physiological function of the target organ. The immune system mediation mechanism is more complex and plays an important role in the development of cancer. Chronic psychological stress can lead to suppression of immune function and cause diseases related to immune function. In animal experiments, neither stressful stimuli alone nor virus inoculation alone caused disease, but the simultaneous presence of both factors resulted in successful virus infection. When depression and frustration occur in response to intense mental stimuli that reduce a person’s ability to cope, there is an increase in blood pro-adrenal hormones and adrenocorticotropic hormones, which suppress the normal function of the immune system. The human immune system is capable of recognizing and resisting foreign substances such as bacteria and viruses that invade the human body, so the body’s susceptibility to various diseases depends to a large extent on the sound functioning of the immune system. Previously, the immune system was thought to be a self-regulating, isolated system. Recent studies have proven that the human brain is able to influence the function of the immune system. This means that the body’s resistance to various illnesses will be influenced by mental emotions. According to some information, Australian experts measured the immune function of 26 subjects who were recently widowed and found that the activity of lymphocytes in the body of the subjects tested was significantly lower than that of people of the same age, sex and race after two months of bereavement, showing a decrease in immunity. The immune system does not function alone, but interacts with the nervous system in two ways: through hormones regulated by the brain and through nerve fibers associated with immune cells, called psychoneural networks. Immunosuppression due to feedback elevation of glucocorticoids in the body after a stressful state is hypothesized to be the mechanism of immunosuppressive effects caused by psychological stress in the hypothalamic pituitary-adrenal axis. Studies on the relationship between some negative psychological states such as anxiety, depression, disappointment and sadness and the immune system have shown that these states are characterized by reduced lymphocyte value-added, reduced natural killer cell activity and altered amounts of leukocyte nuclear antibodies in the blood circulation. In addition, a person’s ability to produce antibodies to foreign substances correlates with the degree of anxiety. Excessive anxiety reduces the antibodies produced by the organism against harmful substances. Moreover, there is a relationship between the duration and nature of stress and the degree of immune alteration. The longer the duration of stress and the greater the degree of pessimism, the greater the decrease in specific types of lymphocytes. Psychological stress is likewise associated with the activity of other systems, including the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Activation of these two systems can cause increased levels of hormones in the blood, especially cortisol, epinephrine and norepinephrine, which are associated with the body’s immune function. Psychological stress can activate the sympathetic-adrenal medullary endocrine axis through the mediation of the limbic system amygdala, causing the release of catecholamines and initiating the PHA axis. The immune system mediates the development of many diseases, including cancer, both in terms of susceptibility qualities and pathogenesis triggers. But how do immune mediators interact with neurophysiological and endocrine mediators to promote psychosomatic diseases? The “neuro-immune-endocrine-network theory” has been proposed, which suggests that the nervous system acts on immune organs through neurotransmitters. The neurotransmitter receptors are located on the immune cells, and the strength of this information transmission determines the activity of the immune cells. Another pathway is the humoral or pituitary peptide adrenocortical hormone system, where both endogenous opiate and non-opiate peptides have immunosuppressive and tumor-promoting effects and can be blocked by specific endorphin antagonists. Psychological stress can impair hypothalamic function and cause an overproduction of corticosteroids, which affects immune function. In this case, degeneration or atrophy of the thymus and lymphoid tissue, suppression of antibody responses, and a decrease in the activity of giant cells can be seen. These reveal the influence of the central nervous system on immune effectors through the endocrine system. 1. Composition of neuro-immuno-endocrine-network (1) Innervation of immune tissues and organs. (2) Immune cells secrete neuropeptides and hormones. (3) Immune cells have neurotransmitters, neuropeptides and hormone receptors. There are receptors for epinephrine, acetylcholine, dopamine and histamine on the immune cell membrane. (4) Neurons and endocrine cells produce a variety of cytokines. (5) Receptors for multiple cytokines are present in neurons and glial cells. 2. Interaction of neuro-immune-endocrine network (1) The effect of stress on immunity and endocrine. Sleep deprivation, widowhood, and various stress-inducing stimuli can lead to a decrease in the body’s immune function. (2) Effects of mental or emotional fluctuations on endocrine and immune function. Mood changes such as loneliness, depression, anxiety and anger can induce the production of cytokines with toxic effects and activate the hypothalamic-pituitary-adrenal axis, resulting in excessive release of glucocorticoids and immunosuppressive effects. Common autoimmune diseases include lupus erythematosus, rheumatoid arthritis, etc. Do not boost your immunity at will, once the balance of the autoimmune system is disturbed and the immune system responds too strongly to its own antigens, like pollen allergy, asthma, etc. The main function of the immune system is to defend against foreign pathogens. The immune system must be able to distinguish between self and non-self, and not respond to what is the organism’s own. The human immune system is kept alive mainly by food. Some food components can assist in stimulating the immune system and increasing immunity. The intake of various nutrients must be very adequate to keep the immune system strong. Protein, vitamin C, E, garlic, onions, green tea, citrus, lemon, tomatoes, carrots, spinach, olive oil, red wine, mushrooms and mushrooms are all rich in antioxidants that activate immune cells and balance the immune system. Then moderate exercise 3-4 times a week for 30-45 minutes of aerobic exercise can improve the body’s immunity. Heart rate (220 – age) X 60% – 70%, the resulting number, that is, the most appropriate exercise heart rate interval. Busy and stressful work groups have reduced immune function and are prone to illness. People with a tendency to have a “high desire for power” or “repressed” personality have a significant decrease in antibodies to their first line of defense in the respiratory tract and are susceptible to respiratory infections. The immune cells become more active as a result of the many immune-related chemicals, such as catecholamines, that are stimulated by joy. A good night’s sleep is good for immunity and vice versa leading to lower immune system function. The period from 11 p.m. to 3 a.m. is when the body’s meridians run to the body’s liver and gallbladder, and the latest time to go to sleep is at 1 a.m. for liver support. Foods that stifle immunity are high in fat, sugar, tobacco, alcohol, coffee, drugs, etc. Abuse of antibiotics can reduce the hormones responsible for coordinating the immune system in some patients. Ensuring a healthy and scientific daily lifestyle is the best way for people to improve the immunity of the body. Stress can have unhealthy effects on the body and mind, such as increased blood pressure, muscle atrophy, and decreased immunity. Cassins proposed the idea of “using humor as a therapy to reduce stress for psychological patients”, and put it into practice. People who are stressed or overstressed can regain positive emotions such as happiness, hope and confidence by smiling from time to time. American immunologists Polk and Stanley found that when people smile, they can promote the movement of beneficial cells in the body to counteract stress-induced immune deficiency. Dr. Locke of Harvard University found that humans who fail to adapt to the ever-changing environment of survival, and as a result lead to stress, mental overload and other mental states, the number of beneficial cells in their bodies will decline substantially, while those who can still maintain an optimistic mindset in the face of adverse circumstances, the number of beneficial cells in their bodies remains largely unchanged. Experiments at the University of Ontario School of Medicine in Canada have shown that when humans watch humorous movies, the indicators of immune function are much higher than when they are depressed or calm. This area of research is becoming an important part of the discipline of “psychoimmunology”, which aims to identify the interaction between human emotions and the immune system. Only people who are relaxed, treat people as equals, are free, relaxed, intelligent and thorough, who expand their knowledge, who are rich in conversation, who are funny, who are optimistic and open-minded, who are inclusive, who are quick-witted and who capture the essence of things quickly, can feel relaxed, enjoy themselves even under harsh living conditions, build an optimistic attitude to life and improve their immune system.