Demyelination is generally defined as white matter demyelination, and patients with mild demyelination changes generally have milder signs and symptoms. The common clinical conditions that cause demyelination changes are central nervous system demyelination changes, the main disease is multiple sclerosis, and peripheral nervous system demyelination changes, common diseases include Greenbrier’s syndrome. If a patient is considered to have Grinbarr’s syndrome, the patient is generally better treated. Early glucocorticoids can be applied to promote the absorption of inflammation, which may allow the demyelinating changes to recover, and commonly used drugs include dexamethasone and prednisone, which are generally more difficult to recover if the lesion involves the axon. The patient can also be treated with B vitamins for nerve nutrition. Commonly used drugs include vitamin B1, vitamin B6, methylcobalamin and adenosylcobalamin, etc. Rehabilitation and acupuncture can be performed after the condition is stabilized. Patients can be cured clinically with active and correct treatment. Multiple sclerosis is a demyelinating change of the central nervous system. After the onset of multiple sclerosis, patients can generally develop various symptoms and signs, mainly depending on the site of lesion involvement, and can develop sensory disorders of the lateral limbs, motor disorders, or various discomforts such as dizziness. Glucocorticosteroids can also be applied in the early stage, the patient is generally poorly treated and the patient can have recurrent attacks after cure.