Gallbladder stones are one of the most common digestive system diseases. Most patients with gallbladder stones are asymptomatic, while a small number of patients with gallbladder stones may induce biliary colic, followed by bacterial infection, manifesting as acute and chronic cholecystitis, and long-term chronic cholecystitis may even develop into gallbladder cancer. Cholecystectomy is the main surgical treatment for symptomatic gallbladder stones. However, the gallbladder has various physiological functions such as storing, concentrating and excreting bile as well as regulating bile duct pressure. The vast majority of patients with gallbladder resection have significantly improved quality of life after surgery. However, a small proportion of patients still have different degrees of abdominal distension, diarrhea, poor appetite, anorexia, bile reflux gastritis and other symptoms after cholecystectomy. A small number of patients may develop persistent chronic diarrhea. Gallbladder stone removal achieves the purpose of stone removal and gallbladder preservation through minimally invasive surgical means, which can avoid the possible digestive symptoms after gallbladder removal and serious complications of cholecystectomy such as common bile duct injury. However, compared with cholecystectomy, the stone recurrence rate is about 10% 5 years after gallbladder stone removal, which is suitable for patients with asymptomatic gallbladder stones who have a strong desire for gallbladder preservation and a functional gallbladder. Suitable for: 1. age 18-75 years; 2. no serious cardiopulmonary disease and able to tolerate general anesthesia surgery; 3. imaging confirmed the presence of stones in the gallbladder; 4. the number of stones does not exceed 5 and the length diameter of a single stone is 0.8-1.5 cm; 5. no gallbladder cervical duct stones; 6. no gallbladder polyp-like lesions; 7. smooth or slightly hairy gallbladder wall with thickness ≤ 2 mm; 8. gallbladder contractile function. Lipid meal test, gallbladder contraction > 50% within 2h after meal; 9, no combined common bile duct stones; 10, all indicators of liver function are within normal range; 11, no metabolic syndrome and family history, all blood biochemical indicators are normal, BMI index ≤ 25.