With the increasing incidence of diabetes, the incidence of diabetic nephropathy is also significantly higher than before, which makes diabetic nephropathy will gradually become one of the main causes of chronic kidney failure, according to data reported in foreign countries, about 30% ~ 50% of diabetic patients can develop diabetic nephropathy. Nowadays, the key to diabetic nephropathy is early diagnosis and treatment. If early diagnosis and treatment are neglected, once patients enter the clinical proteinuria stage, their kidney damage is difficult to be reversed. Diabetic nephropathy is divided into five stages, the first two stages often have no obvious performance, from stage III onwards, that is, the microalbumin phase, early nephropathy, there is proteinuria or obvious increase in blood pressure and deterioration of kidney function, where the microalbuminuria phase is an important turning point in diabetic nephropathy, there are three possible regression: after active treatment will return to normal proteinuria, long-term maintenance at the level of microalbuminuria; gradually develop into a large amount of proteinuria The diabetic nephropathy has three possible outcomes: normal proteinuria will be restored with aggressive treatment and maintained at the level of microproteinuria for a long time; progressive development of massive proteinuria until chronic renal insufficiency and end-stage renal disease. For patients with stage IV or above diabetic nephropathy often have poor treatment effect and quickly progress to renal insufficiency, requiring dialysis treatment. It is worth pointing out that these patients are mostly combined or complicated with various serious cardiovascular and cerebrovascular comorbidities or diabetic retinopathy, fundus bleeding, diabetic neuropathy and other diabetic complications, which makes the risk of dialysis increased. So, how early does Nanjing Hospital Early Diabetic Nephropathy Specialized Clinic for the treatment of diabetic nephropathy actually focus on? The answer is earlier than early. The so-called early stage is the aforementioned stage III, and the focus of treatment in this stage is still on effective control of blood glucose, blood lipids and reduction of urinary protein, etc. Therefore, doctors in this specialized clinic emphasize that intensive control of blood glucose, blood pressure and blood lipids is taken in the clinic, and on this basis, Chinese medicines are given to tonify the kidney and benefit the qi and clear dampness and heat. After clinical practice, they have observed that most patients with stage III diabetic nephropathy have a decrease in urinary microalbumin after treatment. This concept is now recognized by most endocrinologists, and by earlier than earlier, it means that this specialized diabetic nephropathy clinic proposes to focus on patients with diabetes mellitus stage I and II. Stage I, also known as hyperfiltration stage, manifests as elevated glomerular filtration rate, and the physicians of this clinic evaluate the glomerular filtration rate of all newly discovered diabetic nephropathy patients from the early stage of diagnosis, and all patients with elevation are given the following treatment in addition to effective control of blood glucose, lipids In addition to effective control of risk factors such as blood glucose and lipids, antihypertensive drugs are given to patients with elevated rates. Stage II is called the asymptomatic stage. Some patients may present with intermittent microalbuminuria and an elevated or normal glomerular filtration rate. Common factors causing intermittent proteinuria in diabetic patients include: urinary tract infection, ketosis, strenuous exercise, and laboratory errors. Especially for patients with exercise proteinuria, the possibility of diabetic nephropathy stage II should be alerted. For patients in this stage, in addition to blood glucose, blood pressure and lipid control, Chinese herbal medicine should be used to intervene in urinary tract infections and other predisposing factors, which is a more positive concept for diabetic nephropathy intervention and brings many “hidden” benefits to diabetic patients. For patients with early stage diabetic nephropathy, or earlier than early stage diabetic nephropathy, because of the lack of typical symptoms, it is easy to be ignored by patients and doctors, and because of the lack of clear diagnostic basis, there is also a certain basis for medication, but if left unchecked, it is very easy to become clinical stage nephropathy, at this time, Chinese medicine intervention becomes an important means, and has played a very good curative effect and long-term benefits. Physicians at the Early Diabetic Nephropathy Specialized Clinic of the Department of Endocrinology, Nanjing Hospital of Traditional Chinese Medicine recommend that all diabetic patients, especially those with first-onset diabetes, or even those with pre-diabetes and high blood pressure, should visit the hospital in a timely manner to intervene at an earlier stage than earlier to avoid the progression of renal failure.