The most common sexually transmitted disease in the world is the human papillomavirus (HPV) infection of the genital, perineal and anal areas of the epidermolysis bullosa, which accounts for 25-30% of STD patients in China, and hundreds of thousands of new cases each year. It is difficult to treat. In the past, ordinary laser treatment was generally used, but the patient suffered a lot of pain during treatment, slow recovery after treatment, and easy to produce scar stenosis. The first thing you need to do is to use a laser to get a good idea of what you are getting. Under normal conditions, ALA is present in small intracellular amounts and does not itself produce photosensitivity. After exogenous ALA enters the body, it is converted into strong photosensitizers such as protoporphyrin IX in cells, which generates reactive oxygen species and free radicals after illumination with specific wavelengths and energies. HPV-infected cells are actively proliferating, and the accumulated concentration of protoporphyrin IX is higher than that of surrounding normal tissues after administration, and irradiation with light waves of specific wavelengths and energies can destroy the abnormal growth of pathological tissues with less impact on surrounding normal tissues. The wart clearance rate of ALA–photodynamic therapy for acromegaly is 98.42%, but the recurrence rate is significantly lower than that of cryotherapy as well as laser treatment. In terms of safety, the incidence of adverse reactions of ALA-photodynamic therapy was significantly lower than that of cryotherapy, indicating that ALA-photodynamic therapy is safe and effective in the treatment of warts, with a high cure rate and a low recurrence rate, which is worth promoting in clinical practice. Photodynamic therapy safely has the advantages of high clearance rate, low recurrence rate, little trauma, no pain, and few adverse reactions. It is especially suitable for perianal, intra-urethral, intracervical, and recurrent recalcitrant condyloma acuminata, and is the only therapy that can treat HPV subclinical infection, which is the ideal solution for treating condyloma acuminata at present.