In order to obtain reasonable treatment for male infertility, care should be taken to achieve a comprehensive diagnostic analysis before selecting a treatment method, including analysis of the baseline pregnancy rate, analysis of the etiology (with or without known etiology), analysis of the diagnostic classification (single or multiple etiology), analysis of the reproductive links affected and the mechanism of action; analysis of the fertility of the female partner, analysis of the choice of treatment (conventional or assisted reproductive technology treatment ), analysis of expected treatment results, etc., and then choose a reasonable treatment for each individual and inform the infertile couple of the overall treatment plan (from simple to complex, and how to deal with the next step if the current plan fails) to gain the patient’s understanding and cooperation. The main prognostic factors affecting male infertility are: 1. duration of infertility; 2. primary or secondary infertility; 3. semen analysis results; 4. age and fertility of the female partner. Commonly used drugs: 1, anti-estrogens: clomiphene citrate, tamoxifen; 2, androgens: testosterone undecanoate capsules; 3, sperm vitalizers: Carnitine, coenzyme Q10; 4, antioxidants: glutathione, lycopene, tocopherol (vitamin E), vitamin C, multivitamins; 5, gonadotropins: HCG, HMG; 6, gonadotropin-releasing hormone (GnRH) 7.Aromatase inhibitors: testosterone, anastrozole; 8.Anti-lactin: bromocriptine; 9.Vasopressin; 10.Hexketone cocaine; 11.Other drugs: folic acid, zinc preparations, alpha-blockers, thyroxine, steroid hormones, prostaglandin synthase inhibitors (indomethacin), growth hormone, antibiotics; 12.Chinese herbal medicine: may improve semen quality through a variety of action links. It has accumulated more than 2,000 years of experience in China, but the efficacy has to be evaluated by evidence-based medicine.