Cystic fibrosis is a genetic exocrine gland disease that affects mainly the gastrointestinal and respiratory systems and is characterized by pancreatic exocrine dysfunction and abnormally high electrolyte levels in sweat. Early symptoms of cystic fibrosis are a mild cough with pneumonia and atelectasis, a progressively worse cough, mucous sputum that cannot be easily coughed up, and shortness of breath. If the symptoms progress to advanced stages, respiratory failure and pulmonary heart disease can occur. Pulmonary cystic fibrosis usually has chronic obstructive pulmonary lesions and may be associated with small bowel atresia, intestinal torsion, and viscous biliary stasis as a cause of extrahepatic obstruction. The disease may be associated with obstructive jaundice, neonatal hepatitis, and hepatocellular degeneration into giant cells. Some infants may resolve completely on their own, and the disease should be considered in children with a history of meconium ileal obstruction. The disease can present with symptoms associated with liver disease, such as upper gastrointestinal bleeding or splenomegaly due to portal hypertension; with manifestations of hepatic insufficiency, hepatomegaly and growth retardation may be present. If the cholecystogram does not show, it may be cholelithiasis or cholecystitis. The patient’s gallbladder is tiny and almost invisible, and abnormal biliary secretion deposits or abnormal bile composition can block the bile duct. Increased chloride in sweat, and abnormal liver biopsy. In summary, the diagnosis can basically be established. Because the viscous secretions often obstruct the ducts connecting the testes to the prostate, patients with cystic fibrosis may have an impact on fertility if they are not treated properly.