Artificial insemination of husband’s semen is indicated for patients whose husbands have supra-urethral cleft, hypospadias, recalcitrant ejaculation, severe premature ejaculation, retrograde ejaculation, or impotence due to psychological or physical factors. Artificial insemination of donor semen (AID) is indicated for husbands with severe genetic defects or Rh factor incompatibility that can cause miscarriage, premature birth and neonatal malformation or severe fetal hemolytic disease. A comprehensive examination of the sperm donor must be done, including blood hepatitis B surface antigen, blood group, and excluding other infectious diseases, and should also have an understanding of his physical appearance and intelligence. The semen of the same donor should not be used after 6 cases of pregnancy to avoid the possibility of intermarriage of their offspring. The fallopian tubes of the artificial insemination recipient must be open and the ovulation must be normal. Special attention should be paid to the fact that artificial insemination cannot be performed if the female partner has systemic or infectious diseases, severe reproductive organ insufficiency or malformation, or severe cervical erosion. Artificial insemination with donor semen is not a combination of the sperm and egg of the couple, which may raise some ethical and legal issues. On the one hand, artificial insemination of donor sperm solves infertility caused by male factor and also prevents bringing genetic diseases of the male partner to the offspring, which plays a role of eugenics; but on the other hand, artificial insemination cuts off the relationship between childbirth and marriage and becomes mating instead of natural sexual union between husband and wife; applying the sperm of a third party brings a third party relationship to the resulting child, which may destroy the unity of marriage and family The use of a third party’s sperm creates a third party relationship for the resulting child, which may destroy the unity of the marriage and family or the love between the couple and the care of the child. Artificial insemination with donor sperm must be signed by both the recipient couple and the donor couple, specifying that the children born will be owned by the recipient, raised and educated by the recipient, and have the right to inherit from the recipient’s family. Generally artificial insemination should only be used for married couples.