After washing or upstream techniques to treat semen, it improves the density of active sperm, reduces or removes prostaglandins, immunoreactive cells, anti-sperm antibodies and bacteria and debris in seminal plasma, reduces the viscosity of semen, and promotes sperm capacitation and improves sperm fertilization; direct injection into the uterine cavity also avoids AsAb in the cervical mucus, which is simple and safe to administer compared with 1VF, ET and G1FT. Compared with 1VF and G1FT, the technique is simple, the medication is safe, the cost is low, and there is no damage to the patient, so it is the preferred method for cervical infertility and immunologic infertility. However, since the entire reproductive tract of women can have immune reaction, the treatment of semen only removes the antibodies that are loosely bound to sperms, but is ineffective for AsAb that is firmly bound to the surface of sperms, therefore, the pregnancy rate of the immune infertility treatment is only 10-15%. Intrauterine insemination can also improve the quality of eggs and sperm in the treatment cycle, the use of drugs to promote ovulation treatment can correct some endocrine abnormalities that are not conducive to the development of eggs, improving the ability to conceive, unexplained infertility, artificial insemination cycle pregnancy rate can be as high as 20% to 30%.