1, artificial insemination (1) indications ① male infertility due to oligozoospermia, weak spermatozoa, abnormal liquefaction, sexual dysfunction, genital malformations, etc.; ② cervical infertility; ③ reproductive tract malformations and psychological factors leading to infertility such as inability to have sexual intercourse; ④ immune infertility; ⑤ unexplained infertility. (2) contraindications ① one of the men and women suffering from acute infection of the genitourinary system or sexually transmitted diseases; ② one of the parties suffering from serious genetic, physical or mental illness; ③ one of the parties in contact with teratogenic amount of rays, poisons, medicines and is in effect; ④ one of the parties has a serious addiction to drugs and other bad habits. 2, artificial insemination (1) indications ① irreversible azoospermia, severe oligozoospermia, hypospermia and dyszoospermia; ② vasectomy failure; ③ ejaculation disorders; ④ indications ① ② ③, in addition to the irreversible azoospermia, the other need for artificial insemination of donor sperm technology, the medical staff must be clearly explained to the patient: through the cytoplasmic monosperm micro-injection technology may also be able to make their own blood relatives of the offspring. If the patient still insists on giving up the rights and interests of assisted conception by intracytoplasmic monosperm microinjection, he/she must sign the informed consent before assisted conception by donor insemination; ⑤ The male partner and/or the family has serious hereditary diseases that are not suitable for childbearing; ⑥ The mother and child with incompatible blood types cannot get a viable newborn. (2) Contraindications ① The woman suffers from acute infection of the genitourinary system or sexually transmitted diseases; ② The woman suffers from serious genetic, physical or mental illnesses; ③ The woman is exposed to teratogenic rays, poisons, drugs and is in the period of action; ④ The woman has a drug addiction and other bad habits.