With the increase of social pressure, the complexity of sexual relations between people, the prevalence of infertility is rising year by year, seeking medical treatment, in the case of all the traditional treatments have failed, many families for the dissolution of the situation, at this time assisted reproduction technology came into being, and flourished, solved most of the infertility patients of the fertility problem, save a large number of families on the verge of breaking up, for the many patients with infertility to bring happiness! The Artificial insemination is one of the assisted reproductive technologies. Artificial insemination technology plays an important role in the treatment of male infertility and some female infertility, each suitable for artificial insemination technology patients hope to be able to successfully pregnancy as soon as possible, but often things do not go as planned, the success rate of artificial insemination technology in the 15% -25% between the following we discuss the success factors affecting the artificial insemination technology pregnancy: First, the age of the artificial insemination of pregnancy rate of The impact of age on artificial insemination pregnancy rate When the age of more than 30 years old, the pregnancy rate is gradually reduced, more than 35 years old, easy to occur fetal malformation. In artificial insemination by fertilization, the age of both the patient and the couple has a great influence on the pregnancy. With the increase of age, the quality of sperm and eggs are on the decline, and the decline of egg quality may be related to the increase of chromosomal abnormality in eggs, the decrease of mitochondria in eggs, the decrease of cytoplasmic ATP content and the increase of apoptotic changes in the cells of the eggs; with the increase of age, the endometrium undergoes a series of changes in morphology and function which affects the embryo. With increasing age, the endometrium undergoes a series of morphological and functional changes that affect embryo implantation. The decline in sperm quality directly affects the fertilization process and leads to fertilization failure. In the process of donor insemination, the quality of sperm is basically guaranteed because the donor has been screened, but the influence of the age of the woman also exists. Second, the impact of etiology on the pregnancy rate of artificial insemination In male infertility, if accompanied by female infertility factors exist at the same time, the pregnancy rate of artificial insemination will be greatly reduced, such as male semen abnormalities, after the optimization of semen processing, sperm quality has been improved, if the woman if there are cervical factors, the pregnancy rate will be even lower, there are also some women at the same time there is polycystic ovary syndrome, endometriosis, pelvic inflammatory disease, although the doctor’s treatment, more or less will have an impact on the pregnancy rate of artificial insemination. After the doctor’s treatment, more or less will affect the pregnancy rate. Third, the impact of years of infertility on the pregnancy rate of artificial insemination The longer the years of infertility, the lower the success rate of artificial insemination, which may be related to the patient’s mood and emotions. Prolonged infertility makes the patient more stressed, and the patient’s nervousness may affect the regulation of the hypothalamus-pituitary-ovarian axis, resulting in ovulation disorders, or affecting the embryo’s implantation. At the same time, this part of the patient, there may be some other causes of infertility are not fully detected, thus affecting the pregnancy rate. Fourth, the impact of insemination timing on artificial insemination pregnancy rate artificial insemination technology insemination timing is the key to the success of artificial insemination, the doctor through the determination of the patient’s basal body temperature, cervical mucus scoring, ultrasound follicle size monitoring and endometrial thickness measurements, blood, urine estrogen and luteinizing hormone content, etc. to grasp the time of the female party’s ovulation, insemination of the time to be selected in 48 hours before ovulation to the time of the most easy to ovulate within 12 hours after ovulation, the time to be selected in the first 48 hours of ovulation. The time of insemination is chosen from 48 hours before ovulation to 12 hours after ovulation, which is most likely to be successful. Fifth, the impact of the number of cycles of artificial insemination on the pregnancy rate domestic and foreign experts concluded: successful insemination of the average treatment period of 3.5 weeks (3 ~ 5.1 cycles), only when the patient receives more than three treatments, the success rate increased from 17% to 33%, which concludes that artificial insemination treatment needs to be carried out at least three times. As the number of cycles of IUI accumulates, the pregnancy success rate increases. Sixth, the effect of endometrial thickness on pregnancy rate endometrial thickness > 10L, estrogenization is good, conducive to embryo implantation. Some studies have shown that endometrial thickness >14L or <7 L no pregnancy occurs. The endometrial thickness is between 7 and 10 L, and the pregnancy rate increases with the increase of endometrial thickness. Seven, the impact of semen on the pregnancy rate of artificial insemination fresh semen than frozen semen artificial insemination pregnancy rate is high, but there is a risk of infection with certain diseases, it is currently believed that artificial insemination with frozen semen is appropriate, because in the process of freezing semen, itself to make itself subject to a selection, many of the poorly developed sperm can not withstand the changes in the ultra-low temperature and death, while healthy sperm can be retained, the recovery of such sperm can make it possible for the sperm to be recovered, the sperm can be used in a variety of ways. The recovery of such sperm can lead to improved quality, which is conducive to eugenics. Understanding the above influencing factors, deepening the understanding of artificial insemination technology, is conducive to the patient to cooperate with the doctor's treatment, to improve the success rate of artificial insemination technology, doctors and patients work together, in order to enable the patient to get a healthy child as soon as possible.