A more formal medical name for a patient born without a vagina or uterus is MRKH syndrome. These patients are born with a malformation in which the vagina is absent or has a shallow fossa and the uterus is usually peanut-shaped and non-functional, although some patients have a functional uterus. Usually there are no symptoms at birth and the problem is not detected until puberty when the menstrual period is not due. However, surrogacy is currently illegal in China and uterine transplantation is still in the research stage. However, surrogacy is currently illegal in China and uterine transplantation is still in the research stage. For patients with cyclic lower abdominal pain during adolescence, the surgery will be performed during adolescence. We are currently trying various methods to open the uterus and the lower outflow tract to allow menstrual blood to flow from below, but in the long run, the cervical opening tends to be blocked repeatedly, causing problems and not much chance of fertility. For patients without periodic lower abdominal pain and a uterus, the current option is usually to help patients rebuild a vagina in adulthood before they plan to have sex to begin with, and it is not yet possible to transplant another uterus to solve the problem of fertility. There are different methods for reconstructing the vagina. The simplest method is the parietal compression method, which involves using external force to parietalize the shallow cavity, using a soft mold to create an artificial vagina. After a week of discontinuation, the patient improved, and about 2/3 of the patients were successful and did not need surgery. This method has now become Dr. Gong’s preferred treatment for MRKH syndrome in the outpatient clinic. This one method is expensive in persistence, the top pressure may be painful at the beginning, we can use some narcotic painkillers to relieve the pain, usually the pain can be tolerated after passing 2 weeks, no need to use painkillers. After the formation of an artificial cavity of 6-8cm or more, you can try to have sex, and the sex afterwards will help to continue the extension of the artificial vagina. Such a method is simple, inexpensive, safe and fast and should be the treatment of choice for MRKH syndrome. If parietal pressure fails, surgery is considered. The purpose of surgery is not only to create an artificial cavity, but the more important job is to consider how to maintain a vaginal mucosa. The surgically formed cavity is particularly prone to collapse because it is formed by other forces and will also gradually shorten if not used for a long time. The artificial cavity creation surgery is easy and requires different materials to cover the surface of the cavity, such materials are amniotic membrane, biological patch, oral mucosa, skin, peritoneum, intestinal canal, based on the injury point of view, I personally tend to use biological patch or oral mucosa with less damage, the peritoneal method, because it requires pulling down the mucosa in the abdominal cavity, therefore requires laparoscopic surgery and leaves scars on the stomach. The skin flap method is dry because there is no mucus secretion in the vagina after transplantation, and the intestinal canal method is used by many doctors in China, but I think it is relatively more invasive and requires removal of a section of the intestinal canal, so I do not use it much. For patients with MRKH syndrome, it is still difficult to solve the fertility problem. Before surrogacy was legal, it could be solved by surrogacy, but after surrogacy is illegal, we can only consider surrogacy in foreign hospitals for now. Uterine transplantation may be a future approach, and some researchers abroad are experimenting with uterine transplantation, or it may become a reality in a few years.