With the cervical lesions of the young and the reproductive age of the senior age, coupled with the second child of the reverse, cervical lesions in pregnancy has increased the occurrence of the situation, pregnancy colposcopy has become a reality that we must face, can be performed during pregnancy colposcopy? Can colposcopy be performed during pregnancy? What problems do I need to pay attention to during pregnancy? What are the principles of management of cervical lesions in pregnancy? These are the problems we need to solve. 1, physiological changes during pregnancy The cervix undergoes corresponding changes during pregnancy due to the increase in estrogen levels, the cervix increases in size and softens, the cervical canal is turned out, so that the transformed area is exposed and easy to observe, and there is a large range of immature metaplastic epithelium, which is rich in blood vessels and is purple-blue in color. Squamous epithelial basal cell hyperplasia is active, nuclear deep staining and nuclear division, cytology can appear bare nucleated cells or mildly heterogeneous cells, so that there are reports that the rate of cytological examination abnormalities in pregnancy can be as high as 5% or more, when cytological abnormalities should be referred to colposcopy. 2, pregnancy colposcopic features pregnancy under the influence of estrogen, cervical epithelial thickening, cervical ectropion transformed area exposed in the vaginal part of the cervix is easy to colposcopic observation, and colposcopic manifestation of the white reaction of acetic acid is abnormally pronounced, there are exaggerated abnormal colposcopic changes can be made with the cervical ectropion of pregnancy, the white range of the acetic acid, but the heteromorphic blood vessels are not common, if there is no mosaic and heteromorphic blood vessels, simple In the absence of mosaicism and heterogeneous vessels, a simple increase in the extent of the white acetate epithelium is not evidence of progression of the lesion and can be followed up with biopsy to determine the extent of the lesion. Case: 30 years old patient, inadvertent pregnancy during infertility screening, TCT: HSIL, high-risk HPV+, pathologic biopsy: HSIL with glandular involvement, p16 immunohistochemistry ++++. Close follow-up throughout pregnancy, the range of white acetate lesions was seen to increase, but lacked the characteristic manifestations of invasive carcinoma, the lesions seen in postpartum colposcopy were significantly reduced, and the pathology of biopsy again was CIN3. Follow-up all the time in pregnancy 3. Follow-up monitoring intervention in pregnancy For colposcopy in pregnancy, the key is to pay attention to the protection of the pregnant woman and her safety, the checking action needs to be gentle, and the suspected high-level lesions should be pathologically biopsied, and the risk of biopsy is Bleeding and infection, need to use sharp biopsy forceps, never by force tearing biopsy, so as not to cause a lot of bleeding, after biopsy need to give really effective hemostasis, such as gauze ball compression for 24-48 hours, prohibit sexual life. Colposcopy and biopsy should have sufficient informed consent from the patient. Delivery of cervical lesions in pregnancy can be completely in accordance with obstetric principles, cervical lesions are not an indication for cesarean section, and there is no need to go to cesarean section for cervical lesions, and even some scholars believe that vaginal delivery is conducive to the detachment and regression of the lesions, so cervical lesions in combination with pregnancy can be vaginal trial of labor. The diagnosis of cervical lesion can be delayed after clear treatment, close follow-up observation during pregnancy is sufficient, once at 8-12 weeks for colposcopy and cervical cytology follow-up, to be re-colposcopic and pathologic evaluation after delivery, and to manage the results of the evaluation. Cervical conization is not recommended during pregnancy. Case 1 was closely monitored throughout pregnancy and re-biopsied post-partum to administer treatment with post-biopsy pathology results. Follow-up observation of cervical lesions in pregnancy is a test of the wisdom and beliefs of doctors and pregnant women, in the current doctor-patient relationship, the doctor’s courage to take responsibility and careful consideration of the arrangements, the pregnant woman’s absolute trust and understanding of the doctor is a prerequisite for success, if there is a lack of mutual trust is not possible, the doctor’s benevolence should be understood by the recipients, the signing of the informed consent is very important, I have succeeded in monitoring the follow up of the pregnant women are through the I have successfully monitored the follow-up of pregnant women are after good communication, we must remember that communication communication is essential. Because colposcopy in pregnancy involves both the pregnant woman and the fetus, and because the characteristics of colposcopic images are different from those in non-pregnancy, and the judgment criteria are also different from those in non-pregnancy, it is recommended that colposcopy in pregnancy be performed by experienced colposcopists, and that follow-up during pregnancy be performed by multidisciplinary cooperation between obstetricians and gynecologists.